Escherichia coli research studies

This paper engineers gut symbionts to secrete colicins that suppress uropathogenic E. coli colonization in mice.

This study analyzes the capsule operon genetics of E. coli ST131 using 3,033 genomes, identifying a monophyletic group with divergent kpsM and kpsT genes linked to host-pathogen interactions.

This paper shows that IpaH7.8, a Shigella effector, enters human cells without a secretion system, suppresses inflammasome activity, and reprograms kinase signaling to inhibit oxidative burst responses.

This paper analyzes STEC population structure and host-disease associations using whole genome sequencing of 3,418 isolates from 11 European countries, identifying distinct subpopulations linked to disease severity.

The paper identifies non-coli Escherichia species, including clade I ST485, that carry EAEC virulence genes and are often misidentified as E. coli, highlighting their potential role in diarrheal disease.

The paper investigates the invasion of bladder carcinoma cells by different phylogenetic groups of E. coli, finding that group B2 strains preferentially invade differentiated cells, with flagella playing a key role.

This study refines SPATE gene detection in EAEC genomes, revealing phylogeny-associated differences in SPATE distribution and identifying pic as a diarrhoea-associated gene.

The paper analyzes the temporal dynamics and acquisition of stx2a in STEC isolates in England from 2016 to 2024, showing a shift from O157 to non-O157 serogroups and increasing stx2a prevalence.

This study examines phenotypic heterogeneity and environmental regulation of urovirulence in Klebsiella pneumoniae UTI isolates, finding high phenotypic variability and shared colonization ability.

This paper develops a dual-target glycoconjugate vaccine against Shigella sonnei using a carrier protein and O-antigen, showing it elicits IgG responses to both components.

This study characterizes virulence and antimicrobial resistance features of E. coli ST131 strains from Rio de Janeiro, identifying subclade C2 as highly resistant and virulent, contributing to its dissemination.

This paper develops a non-genetically modified C57BL/6 mouse model that develops severe Citrobacter rodentium infection, driven by microbiota changes and impaired early immunity.

The paper identifies genes and mechanisms enabling pathogen persistence in freshwater ecosystems using paired in situ and molecular analyses of Escherichia, Klebsiella, and Enterococcus.

This study investigates how gut-derived short-chain fatty acids affect uropathogenic Escherichia coli behavior and host-pathogen interactions at the colonic epithelial interface.

The paper analyzes genetic variation in virulence factors of non-O157 STEC genomes and models their protein interactions to assess pathogenic potential.

The paper identifies a conserved CRISPR spacerome signature across globally distributed E. coli strains, suggesting its potential as a marker for epidemiological tracking.

This study uses CRISPRi to identify genetic factors affecting E. coli adaptation across diets, inflammation, and strains in a mouse model.

This study investigates CLAP in LEE-negative STEC, showing chain formation dynamics and genetic diversity, with claB prevalence and EibG's role in virulence.

The paper isolates antibodies from a Shigella outbreak in non-human primates, showing some target O-antigen and T3SS proteins, with some antibodies enhancing virulence.

This paper optimizes and scales up EIT antigen production in E. coli fermentations for a cattle vaccine against EHEC, achieving 350 doses per liter.

This study examines how Enterococcus faecalis affects the transcriptome and metabolism of Escherichia coli in co-culture, revealing strain-specific responses and nutrient cross-feeding.

This study shows that the lac operon in uropathogenic E. coli enables host glycan utilization, enhancing intracellular growth and infection dissemination.

The paper identifies a prophage-encoded sRNA, HnrS, that counteracts xenogenic silencing by repressing Hha, enabling virulence gene expression in E. coli.

The paper investigates the evolutionary dynamics of colibactin production and resistance in E. coli, showing clonal expansions linked to co-evolution between production and immunity.

This study investigates the role of P-like fimbriae in avian pathogenic Escherichia coli, showing their species- and tissue-specific adherence and potential zoonotic risk.

This study uses CRISPRi to identify metabolic vulnerabilities of UPEC in urine, highlighting ALS II as a druggable target.

This study uses live-cell single-molecule microscopy to show that cytosolic T3SS proteins bind to injectisomes with dynamics influenced by effector presence and secretion state.

This study analyzes the genomic diversity, antimicrobial resistance, and virulence factors of E. coli isolates from diabetic foot infections, revealing high multidrug resistance and virulence potential.

The paper identifies 14-3-3ζ and CAP2 as host proteins required for actin remodeling during Shigella flexneri entry, showing their coordinated role in membrane ruffle formation.

This study isolates and identifies Escherichia coli from calves in Ethiopia and determines its antimicrobial susceptibility patterns, finding higher prevalence in diarrheic calves and multidrug resistance.