Ultrasound and Hyperthermia Applications

This study develops a method to apply focused ultrasound neuromodulation in awake, head-fixed mice with temporal lobe epilepsy and evaluates its effects on seizure-like events.

This study uses LIFU to target brain regions involved in the HEP and finds that PI modulation decreases HEP amplitudes.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

This study shows focused ultrasound enhances gene delivery to deep brain structures when recombinant adeno-associated virus is administered in the cerebrospinal fluid.

This study shows that transcranial focused ultrasound can modulate activity in the extrastriate visual cortex with subregion specificity when targeting the prefrontal cortex in rhesus macaques.

This paper introduces acoustomechanically activatable liposomes with sucrose that enable noninvasive, on-demand ultrasound-targeted drug delivery without cavitation or heating.

This study uses ultrasound flow imaging to detect blood volume reduction and vasoconstriction after FUS-induced BBB opening in mice.

This paper introduces RAID, a noninvasive method to control specific brain cell types using ultrasound and enzyme-prodrug pairs for sustained neuromodulation.

Transcranial focused ultrasound reduces neuromelanin accumulation and provides therapeutic benefits in parkinsonian rats without additional interventions.

This study uses low-intensity focused ultrasound to non-invasively modulate the dorsal anterior cingulate cortex, reducing pain perception and altering cardiovascular responses to heat pain.

This study uses low-intensity focused ultrasound to non-invasively target specific sub-regions of the human insula, showing differential effects on pain perception and heart-rate variability.

This study compares the effects of focused ultrasound alone versus with microbubbles on functional connectivity in non-human primate brains.

This paper develops a method to improve the effectiveness and safety of transcranial focused ultrasound by compensating for skull and scalp attenuation and distortion.

This study shows that transcranial focused ultrasound can safely and sustainably modulate deep brain circuits in awake non-human primates, affecting behavior and neural activity.

This study shows tFUS increases neural firing and induces frequency-dependent correlation changes in rat somatosensory cortex neurons.

This study demonstrates that sonogenetics can selectively activate defined neural circuits and induce specific behaviors in freely moving mice through ultrasound stimulation.

This study uses MR-guided TUS to modulate visual evoked potentials and cortical oscillations in a sheep model by targeting the lateral geniculate nucleus.

Nitrous Oxide reduces microbubble and ultrasound pressure requirements for BBB opening and improves AAV9 vector delivery.

TUSX provides an open-source MATLAB toolbox for transcranial ultrasound simulation using subject-specific medical images and validates it with water tank pressure measurements.

This study shows that amplitude-modulated transcranial focused ultrasound (AM-tFUS) differentially affects excitatory and inhibitory neurons in the rat hippocampus based on intensity.

This paper demonstrates a method using gas-filled nanostructures to enhance and selectively control ultrasound neuromodulation of neurons.

This study identifies the mechanism by which focused ultrasound excites neurons through mechanosensitive calcium channels and ion channel amplification.

This study shows transcranial ultrasound can bias decision-making in non-human primates by modulating oculomotor circuits, with effects comparable to neuromodulatory drugs.

This study shows tFUS selectively affects excitatory and inhibitory neurons and induces long-term synaptic changes in rats.

This study evaluates the safety of transcranial focused ultrasound (tFUS) for human neuromodulation, finding no serious adverse effects and minor transient symptoms reported.

This study identifies radiation force as the physical mechanism of ultrasonic neurostimulation in ex vivo salamander retina, showing frequency-dependent stimulation and standing wave effects.

This study shows that focused ultrasound improves visual-motor decision-making in monkeys and interacts with haloperidol, suggesting a role for the dorsal striatum in decision-making.