Ultrasound and Hyperthermia Applications

Behavioral effects of targeting the central thalamus and pulvinar with transcranial ultrasound stimulation in healthy volunteers

This study uses tFUS to show that stimulating the central thalamus impairs vigilance and the pulvinar affects visuospatial attention in healthy volunteers.

Development and Characterization of Ultrasound-Activated Polymeric Microdroplets for Targeted Chemotherapy

This paper develops ultrasound-activated microdroplets for targeted chemotherapy, showing high drug encapsulation and pressure-dependent release.

Acoustically activatable drug-loaded nanodroplets for mechanochemical therapy in solid tumors

This paper develops acoustically activatable nanodroplets for targeted drug delivery and mechanical tumor disruption, showing improved tumor control and survival in vivo.

Ultrasound-activated drug release with extracellular vesicles

This paper develops ultrasound-responsive extracellular vesicles for targeted drug delivery to the nervous system, demonstrating controlled release and pain modulation in rats.

Ultrasonic Reporter of Kinase Activity

This paper introduces an ultrasonic reporter of kinase activity (UReKA) to monitor PKA activity in opaque tissues by altering ultrasound scattering of gas vesicles.

Development of Visually Indistinguishable Acoustic Coupling Pads for Double-Blind Focused Ultrasound Neuromodulation Studies

This paper develops and validates visually and mechanically indistinguishable acoustic coupling pads for double-blind tFUS studies, achieving precise control over ultrasound transmission and blocking.

Preclinical Evaluation of Molecular-Targeted Ultrasound Contrast Agents in a Rabbit Model

This study evaluates PSMA-targeted nanobubbles in a rabbit model to improve prostate cancer detection via ultrasound, showing enhanced tumor targeting and retention compared to conventional microbubbles.

Focused Ultrasound Thermal Ablation and CD40 Agonism Reprograms Breast Tumor Immunity to Drive Regression and Memory

This study shows that combining focused ultrasound thermal ablation with CD40 agonism enhances tumor immunity, leading to durable regression and immunological memory in breast cancer models.

The Modulation of the Blood-Brain Barrier by Focused Ultrasound Stimulates Oligodendrogenesis

This study shows that focused ultrasound-mediated BBB modulation increases oligodendrogenesis by stimulating OPC proliferation in the hippocampus and striatum.

Cell-Type-Specific Bidirectional Modulation of the Cortico-Thalamo-Cortical Sensory Pathway by Transcranial Focused Ultrasound (tFUS)

This study shows tFUS can modulate sensory pathways in rats in an excitatory or inhibitory manner depending on stimulation parameters, mediated by specific neuronal populations.

Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation

This study demonstrates acoustoelectric neuromodulation as a mechanism for non-invasive brain stimulation, showing its contribution to ultrasound effects on neural activity.

Acoustic Coupling for Double-Blind Human Low-Intensity Focused Ultrasound Neuromodulation

This paper develops a double-blind coupling device for low-intensity focused ultrasound neuromodulation, demonstrating acoustic transparency and energy control.

Multi-focal ultrasound neuromodulation to the dorsal anterior cingulate cortex disrupts behavioural and neural pain processing

This study investigates the effects of multi-focal ultrasound neuromodulation on the dorsal anterior cingulate cortex (dACC) in healthy participants, finding delayed analgesic effects and altered neural connectivity related to pain processing.

Cryoablation temperature monitoring with dense ultrasonic speed-of-sound shift imaging

This paper introduces a method to monitor temperature changes during cryoablation using ultrasound-based slowness-shift imaging, showing linear and exponential relationships in different tissues.

Noninvasive focal gene transfer of chemogenetic proteins in the primate brain

This study demonstrates noninvasive delivery of chemogenetic proteins to the primate brain using focused ultrasound, enabling activation of long-range frontal cortex circuits without surgery.

Histotripsy-initiated immune response synergizes with chemotherapy in a neuroblastoma murine model

This study shows histotripsy enhances chemotherapy effectiveness in a neuroblastoma mouse model by inducing a systemic immune response and altering the tumor microenvironment.

Flexible Skull-Conformal Phased Array for Aberration-Corrected Transcranial Focused Ultrasound Therapy

This paper introduces a flexible skull-conformal phased array for transcranial focused ultrasound therapy, demonstrating improved focusing and aberration correction in a human skull.

Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network-level activity

This study uses low-intensity focused ultrasound to modulate human amygdala activity and finds it alters emotional processing and reaction times to ambiguous stimuli.

Low-intensity transcranial focused ultrasound engages parvalbumin-positive GABAergic interneurons in a humanized mouse model of chronic pain: from electrophysiology to cellular investigation

This paper investigates how low-intensity tFUS modulates inhibitory neural circuits in a humanized chronic pain mouse model, showing increased GAD67 and PV expression and restored E/I balance.

Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation

This study shows that combining transcranial focused ultrasound with transcranial electric stimulation induces location-specific cortical activation in resting humans, suggesting tFUS has subthreshold modulatory effects.

Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions

This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.

Rapid modulation of choice behavior by ultrasound on the human frontal eye fields

This paper demonstrates that transcranial ultrasonic stimulation (TUS) modulates saccadic eye movements in humans with high spatial and temporal precision, and shows that baseline GABAergic inhibitory tone predicts response variability.

Microbubble Backscattering Intensity Improves the Sensitivity of Three-dimensional (3D) Functional Ultrasound Localization Microscopy (fULM)

This paper introduces backscattering fULM (B-fULM) to improve 3D functional ultrasound imaging sensitivity by integrating microbubble amplitude with count-based localization.

Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles

This study shows that ultrasound-activated nanobubbles reduce tumor stiffness and enhance lipid nanoparticle delivery and immunotherapy efficacy.

Unilateral online ultrasound stimulation of early visual cortex suppresses responses to contralateral visual stimuli

The paper shows that unilateral TUS of early visual cortex suppresses contralateral visual responses, indicating online neuromodulatory effects and dose-dependent suppression.

In vivo tracking of CAR-T cells in tumors via nanobubble-based contrastenhanced ultrasound

This paper demonstrates a method to track CAR-T cells in vivo using nanobubble-based contrast-enhanced ultrasound, showing effective visualization in both tumor-bearing and non-tumor-bearing mice.

Impact of Focused Ultrasound on the Cellular Network of Liver Tissue: A New Perspective for Thermal Lesion Detection

This paper shows that HIFU treatment causes anisotropic changes in liver tissue detectable via backscattering coefficient, linking energy delivery to tissue response for thermal lesion monitoring.

Non-invasive Ultrasonic Neuromodulation of the Human Nucleus Accumbens Impacts Reward Sensitivity

This study shows that non-invasive ultrasound stimulation of the human nucleus accumbens affects reward processing and learning, similar to deep brain stimulation.

Repeated blood-brain barrier opening using low-intensity pulsed ultrasound mitigates amyloid pathology

This study shows that repeated BBB opening using LIPU reduces amyloid pathology in a mouse model of Alzheimer's disease.

Ultrasonic rewarming of cryopreserved alginate encapsulated liver spheroids

This study compares ultrasonic rewarming with a water bath for cryopreserved liver spheroids, finding faster rewarming times but mixed effects on viability.