Sleep and Wakefulness Research

This study shows that NMDA receptors in the hypothalamus are critical for stabilizing NREM sleep and enabling REM sleep by regulating calcium signals and neural activity.

This study investigates how time of day affects generalization ability, finding better performance in the morning than the evening, with no benefit from sleep.

The paper examines sleep-wake regulatory nuclei in rats using long-term single- and multi-unit recordings, finding differences in activity profiles compared to previous studies when correlated with cortical and behavioral data.

The paper investigates high frequency oscillations during NonREM sleep, finding that fast oscillations are associated with memory consolidation after learning, while slow oscillations are not.

This study shows that sleep-dependent gains in visual perceptual learning are better explained by a learning-dependent model than a use-dependent model.

The paper shows sleep loss disrupts hippocampal memory consolidation by activating somatostatin interneurons and cholinergic inputs, which inhibit memory-related activity.

The paper examines how learning and sleep affect ribosomal mRNA profiles in hippocampal neurons, finding that sleep loss disrupts post-learning transcript changes more in active neurons.

SIESTA automates sleep staging in rodents using machine learning, achieving high F1 scores for wakefulness, REM, and NREM sleep stages.

The paper identifies a circuit pathway in mice where sleep-deprived prefrontal cortex neurons trigger nesting and sleep via connections to the preoptic and hypothalamus.

This study shows that adolescent sleep disruption impairs adult social novelty preference, with NREM and REM sleep affecting sociality and novelty preference respectively.

This study shows that an exaggerated postnatal surge of orexin neurons in SHRs contributes to higher blood pressure, and reducing these neurons lowers blood pressure.

This study investigates how dopamine affects memory consolidation during sleep, finding that it enhances forgetting of weak memories and increases slow wave sleep duration.

This study shows that hypothalamic stimulation increases cortical activity and accelerates sleep pressure buildup, indicating the hypothalamus regulates both state transitions and within-state arousal intensity.

The paper introduces composite EEG measures for NREM sleep based on power law scaling, reducing 191 metrics to four, and shows their utility in characterizing age, sex, and intelligence effects.

This study investigates how chronic antidepressant treatments affect REM sleep theta power in a rat model of depression, finding that they increase theta power while reducing REM duration and bouts.

This study investigates how ventral striatopallidal neurons modulate orexin/hypocretin neuron activity in response to food and metabolic states, revealing their role in reward-seeking behavior.

This study investigates how biological sex influences active-phase sleep behavior in mice, finding that sex chromosome complement affects sleep recovery but not spontaneous sleep.

This study shows that electrocortical temporal complexity decreases during sleep regardless of electrode configuration, suggesting brain-generated differences in complexity between wakefulness and sleep.

This study shows that IGF-I modulates stress vulnerability via orexin neurons, with Firoc mice lacking IGF-I receptors in these neurons showing heightened fear responses and PTSD-like behaviors.

This study shows that acute sleep restriction improves memory and sleep quality in old mice but worsens these outcomes in young mice.

This study identifies a Vamp2 mutation in mice that causes sleep-wake transition deficits by reducing synaptic release probability.

This study develops mathematical models of sleep homeostasis in mice, showing Process S integrates local cortical neuronal activity over time to regulate sleep quantity.

This study shows that mefloquine, a gap junction blocker, impairs sleep-dependent declarative memory consolidation in humans but not procedural memory.

This study investigates the role of the paternally expressed Snord116 gene in hypothalamic orexin neurons and its impact on sleep and metabolic functions in mice with paternal deletion of Snord116.

This study shows that REM sleep deprivation in rats causes hepatocyte apoptosis, which is partially reversed with sleep recovery.

This study investigates the role of Snord116 in regulating sleep patterns and cortical neuronal activity in a PWS mouse model, finding abnormalities in REM sleep and sleep spindles.

This paper develops and validates noninvasive electric field sensors for accurate 3-state sleep scoring in mice, achieving high agreement with expert EEG/EMG scoring.

The paper investigates how different types of gist are affected by sleep, finding that REM sleep negatively impacts statistical learning but not inferential gist.

This study investigates how VTA-GABAergic neurons change their activity across sleep/wake states and in response to stimuli, showing distinct correlations with cortical oscillations compared to dopaminergic neurons.