Immune Cell Function and Interaction

Crystal structure of the human NKR-P1 bound to its lymphocyte ligand LLT1 reveals receptor clustering in the immune synapse

The paper solves the crystal structures of NKR-P1 and its complex with LLT1, revealing how clustering enhances inhibitory signaling in the immune synapse.

KIR2DL4 genetic diversity in a Brazilian population sample: implications for transcription regulation and protein diversity in samples with different ancestry backgrounds

The paper characterizes KIR2DL4 genetic diversity in a Brazilian population, identifies new sequences, and shows ancestry influences allele frequencies.

An Optimal Control Approach for Enhancing Natural Killer Cells' Secretion of Cytolytic Molecules

This paper develops a mathematical framework to enhance NK cell secretion of cytolytic molecules by optimizing phosphatase inhibition and synthetic Notch signaling based on stimulation frequency.

Accurate and Efficient KIR Gene and Haplotype Inference from Genome Sequencing Reads with Novel K-mer Signatures

The paper introduces KPI, a method to accurately infer KIR genes and haplotypes from genome sequencing reads using novel k-mer signatures, achieving high accuracy on synthetic and real data.

A Detailed View of KIR Haplotype Structures and Gene Families as Provided by a New Motif-based Multiple Sequence Alignment

The paper generates and aligns KIR haplotypes at high resolution, defines them as 14 loci with 9 genes, and applies the alignments in software tools for haplotype annotation and genotyping.

Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes

The paper presents a method using long-read sequencing to efficiently assemble and annotate diploid human KIR haplotypes with high accuracy and coverage.

Landscape and dynamics of the transcriptional regulatory network during natural killer cell differentiation

The paper identifies two transcription factor clusters regulating NK cell differentiation and highlights FOSL2 and EGR2 as essential for NK cell maturation and function.

Enhancing network activation in Natural Killer cells: Predictions from in silico modeling

This study uses in silico modeling to predict strategies for enhancing NK cell activation by analyzing the CD16, 2B4, and NKG2D signaling pathways.

Revealing Complete Complex KIR Haplotypes Phased By Long-Read Sequencing Technology

The paper uses long-read sequencing to phase and sequence sixteen KIR haplotypes from eight individuals, revealing novel structures and variants.

Improved full-length killer cell immunoglobulin-like receptor transcript discovery in Mauritian cynomolgus macaques

The paper improves KIR allele discovery in Mauritian cynomolgus macaques using high-throughput sequencing and develops a new target capture reagent, finding nine novel alleles.