Peroxisome Proliferator-Activated Receptors

Pparα and fatty acid oxidation coordinate hepatic transcriptional architecture

The paper shows that Pparα and fatty acid oxidation coordinate hepatic transcriptional architecture during fasting, with Ppar driving enhancer priming and acetylation independent of fatty acid oxidation.

Diet-dependent Natriuretic Peptide Receptor C expression in adipose tissue is mediated by PPARγ via long-range distal enhancers

This study identifies PPARγ as a regulator of Nprc gene expression in adipocytes through long-range enhancers, linking it to diet-induced changes in adipose tissue.

Network Modeling and Inference of Peroxisome Proliferator-Activated Receptor Pathway in High fat diet-linked Obesity

The paper models the PPAR pathway using a Bayesian approach to identify sub-pathways involved in HFD-induced obesity and suggests potential therapeutic targets.

Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR signaling

The paper identifies PLAAT3 loss-of-function mutations in humans causing lipodystrophy and insulin resistance by impairing arachidonic acid-mediated PPAR signaling in adipose tissue.

Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues

This study investigates how PPARβδ ligands modulate inflammation in rat lung tissues, finding that agonists promote pro-inflammatory effects while antagonist-agonist combinations induce anti-inflammatory responses.

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

This study shows MED1 is essential for postnatal adipose expansion and de novo lipogenesis gene induction in mice, but not for adipose development or early adipogenesis.

An upstream open reading frame represses translation of chicken PPARγ transcript variant 1

This study identifies an upstream open reading frame (uORF) in the 5' UTR of chicken PPARγ1 that represses its translation.

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

The paper investigates how different PGC-1α isoforms regulate hepatic metabolism and apoptosis in response to inflammation, identifying distinct roles for PGC-11 and PGC-14.

PPARβ/δ recruits NCOR and regulates transcription reinitiation

This study investigates how PPARβ/δ inverse agonists repress transcription by recruiting NCOR and interfering with transcription factor recruitment.