Peroxisome Proliferator-Activated Receptors

PPARγ brakes cytosolic DNA-induced macrophage inflammation by super-enhancer metabolic reprogramming

This study shows PPARγ suppresses cytosolic DNA-induced macrophage inflammation by reprogramming metabolism and inhibiting inflammatory gene expression through super-enhancer remodeling.

PPARα-dependent effects in the liver and jejunum of mice in response to pemafibrate

This study examines pemafibrate's tissue-specific transcriptional effects in PPAR-dependent mice, showing strong responses in liver and jejunum but not in other tissues.

Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm

This study develops a mathematical model of PPARγ dynamics to show stress-induced adipogenic commitment is a bistable, irreversible process regulated by circadian rhythms.

Dexamethasone-induced PPARG expression in osteogenic differentiation in vitro: impact on SOX9 and RUNX2 levels.

This study investigates the role of PPAR-γ in dexamethasone-induced osteogenic differentiation of human BMSCs, finding no significant effect of PPAR-γ inhibition on SOX9 or RUNX2 levels.

CDC14 phosphatases control adipogenesis via PPARγ de-phosphorylation

This study shows CDC14 phosphatases regulate adipogenesis by dephosphorylating PPARγ, improving glucose metabolism and preventing obesity in mice.

Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety

This paper identifies a small molecule inhibitor of PPARγ acetylation that improves insulin sensitivity and browning of white adipose tissue without the side effects of traditional PPARγ agonists.

PPARgene 2.0: leveraging large language models and multi-omics data for enhanced identification and prediction of PPAR target genes

PPARgene 2.0 updates the database with new PPAR target genes and improves prediction using language models and ChIP-seq data.

PPAR-delta rather than PPAR-gamma is likely to be the key modulator of central carbon metabolism in human adipocytes

This study investigates the role of PPAR-delta versus PPAR-gamma in modulating central carbon metabolism during adipogenesis in human adipocytes using real-time qPCR and metabolic arrays.

Nutrient-Sensing Nuclear Receptor PPARα Controls Liver Proteostasis

This study identifies PPARα as a regulator of liver proteostasis, showing it suppresses protein synthesis and secretion while enhancing proteasome activity and degradation.

Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers

Trifluoroacetate reduces plasma lipid levels and the development of atherosclerosis in mice

This study shows that trifluoroacetate reduces plasma lipids and atherosclerosis in mice by activating PPAR-alpha, but also highlights its environmental and clinical relevance.

Adipogenic differentiation and inflammatory response is orchestrated by regulating euchromatic histone methyltransferases.

This study shows EHMT1 and EHMT2 regulate adipogenesis and inflammation by controlling gene expression and histone modifications, with EHMT1 governing PPAR and EHMT2 affecting H3K9me2 levels.

Expression and molecular regulation of key genes during adipogenesis of neural crest stem cells

The paper identifies key genes involved in NCSC adipogenesis through mRNA sequencing, RT-qPCR, and RNAi, revealing a positive feedback loop between C/EBPβ and PPARγ.

miR-223 Plays A Critical Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity

The paper identifies miR-223 as a key regulator of TBT-induced adipogenesis in MSCs and its transgenerational role in obesity.

Early Signaling Events in Renal Compensatory Hypertrophy Revealed by Multi-Omics

The paper identifies PPAR activation as a key driver of compensatory renal proximal tubule hypertrophy using multi-omic analyses in a mouse model.

A dynamic HIF1alpha-PPARgamma circuit controls a paradoxical adipocyte regulatory landscape

The paper identifies a dynamic HIF1alpha-PPARgamma circuit that both promotes and represses lipid accumulation during adipogenesis, revealing a mechanism for adipocyte dysfunction in obesity.

Pparα and fatty acid oxidation coordinate hepatic transcriptional architecture

The paper shows that Pparα and fatty acid oxidation coordinate hepatic transcriptional architecture during fasting, with Ppar driving enhancer priming and acetylation independent of fatty acid oxidation.

Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR signaling

The paper identifies PLAAT3 loss-of-function mutations in humans causing lipodystrophy and insulin resistance by impairing arachidonic acid-mediated PPAR signaling in adipose tissue.

PPARβ/δ recruits NCOR and regulates transcription reinitiation

This study investigates how PPARβ/δ inverse agonists repress transcription by recruiting NCOR and interfering with transcription factor recruitment.