Peroxisome Proliferator-Activated Receptors

PPARγ-dependent and -independent regulation of methionine metabolism by diet-induced obesity and fasting in male mice.

This study investigates how diet-induced obesity and fasting affect methionine metabolism in the liver, showing that PPARγ regulates key genes in this process, with distinct effects under different metabolic conditions.

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

The paper identifies a feedback loop between SETD6-mediated methylation of PPARγ and lipid metabolism gene expression in liver-derived cells, linking it to lipid accumulation and disease.

Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

The paper investigates how covalent inhibitors of PPARγ shift its conformational state, affecting ligand binding and inhibitor efficacy.

Intestinal stem cell marker MEX3A regulates PPARγ expression with functional impact in colorectal carcinogenesis

This study shows MEX3A regulates PPARγ expression in colorectal cancer, affecting tumor growth and chemotherapy response.

A Study on the Pharmacokinetic/Pharmacodynamic Profiles of the Novel PPAR Pan Agonist Chiglitazar Sodium in Rats with Hypoalbuminemia

This study compares the PK/PD profiles of Chiglitazar Sodium in healthy rats and those with hypoalbuminemia, finding no significant differences except for Tmax.

PPARgamma, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retrodifferentiation in human hepatocellular carcinomas

This study identifies PPARgamma as a key regulator of metabolic reprogramming and stemness in hepatic CSCs, linking it to chemoresistance in HCC.

Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909

This study compares FX-909 to other covalent PPARγ inverse agonists, showing improved corepressor-selective inverse agonism and stabilization of a repressive conformation.

Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPARγ-mediated adipocyte differentiation.

This study shows that Cnot4 heterozygosity reduces obesity in mice on a high-fat diet by impairing PPARγ-mediated adipocyte differentiation without affecting metabolic gene expression or serum levels.

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

The paper identifies transcriptional cascades during fasting that amplify gluconeogenesis and trigger a secondary wave of ketogenic gene transcription through hormone-induced transcription factors.

Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARgamma

This study reveals that covalent PPARgamma inhibitors like GW9662 and T0070907 weaken but do not block binding of other synthetic ligands through an allosteric mechanism, altering the receptor's conformation and ligand binding affinity.

Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407

The paper identifies ZFP407 as a novel PPARγ cofactor that regulates adipocyte function through direct DNA binding and interaction with the PPARγ/RXRα complex, independent of post-translational modifications.

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

Alternatively Spliced Landscape of PPARγ mRNA in Podocytes is Distinct from Adipose Tissue

The paper identifies distinct PPARγ mRNA variants in podocytes compared to adipose tissue, highlighting differences in splicing patterns and regulatory mechanisms.

Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease

The paper uses BoNE to identify dual PPARα/γ agonism as a therapeutic strategy for IBD, validated in preclinical models and patient-derived cells.

Selective Modulator of Nuclear Receptor PPARy with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome

This study compares the effects of GQ-16, a PPARγ partial agonist, and pioglitazone, a PPARγ full agonist, in treating nephrotic syndrome in rats, finding that GQ-16 reduces proteinuria and co-morbidities with fewer adipogenic side effects.

Diet-dependent Natriuretic Peptide Receptor C expression in adipose tissue is mediated by PPARγ via long-range distal enhancers

This study identifies PPARγ as a regulator of Nprc gene expression in adipocytes through long-range enhancers, linking it to diet-induced changes in adipose tissue.

Network Modeling and Inference of Peroxisome Proliferator-Activated Receptor Pathway in High fat diet-linked Obesity

The paper models the PPAR pathway using a Bayesian approach to identify sub-pathways involved in HFD-induced obesity and suggests potential therapeutic targets.

Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues

This study investigates how PPARβδ ligands modulate inflammation in rat lung tissues, finding that agonists promote pro-inflammatory effects while antagonist-agonist combinations induce anti-inflammatory responses.

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

This study shows MED1 is essential for postnatal adipose expansion and de novo lipogenesis gene induction in mice, but not for adipose development or early adipogenesis.

An upstream open reading frame represses translation of chicken PPARγ transcript variant 1

This study identifies an upstream open reading frame (uORF) in the 5' UTR of chicken PPARγ1 that represses its translation.

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

The paper investigates how different PGC-1α isoforms regulate hepatic metabolism and apoptosis in response to inflammation, identifying distinct roles for PGC-11 and PGC-14.