Toxoplasma gondii Research Studies

This study identifies and characterizes a Toxoplasma gondii O-glycosyltransferase, T.gondii-GalNAc-T3, revealing structural and functional differences from host homologues and identifying potential drug targets for parasitic diseases.

This study investigates the role of Toxoplasma gondii type II effector GRA15 in vivo, finding it has a limited impact on brain parasite burden and immune cell numbers at 3 weeks post-infection.

This study examines how iron depletion affects different Toxoplasma gondii strains, finding that acute strains are more sensitive than cystogenic strains.

This study identifies a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein in Toxoplasma gondii that exhibits enzymatic activity but does not affect intracellular growth under hypoxia.

This paper identifies GRA47 and GRA72 as Toxoplasma gondii pore-forming proteins that regulate small molecule permeability of the parasitophorous vacuole, with mutations affecting their function and virulence.

This study shows SPARK regulates PKA and PKG stability in Toxoplasma gondii, affecting its asexual cycle transitions.

The paper identifies a novel narnavirus, Apocryptovirus odysseus, potentially infecting Toxoplasma gondii, and suggests it may act as a pro-inflammatory factor in host cells.

This paper identifies TgUUT1 as a key pyrimidine salvage transporter in Toxoplasma gondii and demonstrates that 5F-uracil derivatives are potent antiparasitic agents with efficacy comparable to sulfadiazine.

The paper describes an outbreak of toxoplasmosis in captive primates during the COVID-19 pandemic, identifying Toxoplasma gondii as the causative agent through a collaborative, interdisciplinary investigation.

This study shows that Toxoplasma gondii infection causes complement-dependent loss of inhibitory synapses on excitatory pyramidal neurons in the neocortex.

This study shows that IFN-γ stimulated murine and human neurons can clear Toxoplasma gondii parasites, challenging the dogma that neurons cannot mount anti-parasitic defenses.

The paper reports a novel fragmented mitochondrial genome in Toxoplasma gondii and related tissue coccidia, revealing a unique genome architecture and cytochrome gene structure.

The paper reevaluates the genomes of Toxoplasma gondii and Neospora caninum, revealing misassembly, chromosomal rearrangements, and new genes, with implications for genome-based comparative biology.

This paper uses third-generation sequencing to revise the molecular karyotype of Toxoplasma gondii, identifying chromosome fusions and copy number variants in sexual recombinants.

This study investigates the effects of Toxoplasma gondii infection on a 3D human brain model, showing changes in morphology, gene expression, and inflammation.

The paper uses single-cell RNA sequencing to show that CD16- monocytes are key in the transcriptional response of human monocytes to Toxoplasma infection, revealing transcriptional heterogeneity and cytokine secretion patterns.

The paper uses RNA-seq to compare transcriptional profiles of neurons infected with Toxoplasma gondii, bystander neurons, and controls, finding immune cell transcripts enriched in infected neurons.

This study shows that endocytosis is essential for gliding motility in Toxoplasma gondii, as it enables retrograde membrane flow and the recycling of surface proteins.

This study examines how chronic Toxoplasma gondii infection affects social behavior and neural circuits in female mice, identifying molecular changes in brain regions associated with social behavior.