Advanced Neuroimaging Techniques and Applications

3D Histology Validates 2D Histology for Axon Radius Distributions and Conduction Velocities

The paper validates 2D histology for representing axon radius distributions and conduction velocities using 3D reconstructions of rat axons and applies this to human data.

Mapping the topographic organization of the human zona incerta using diffusion MRI

This study maps the topographic organization of the human zona incerta using diffusion MRI and connectivity analysis, revealing gradients and clusters linked to specific cortical regions and functions.

Insights into Temporal and Spatial Dynamics of Short Association Fiber Formation in the Human Fetal Brain

This study reconstructs the development of short association fibers in the human fetal brain using diffusion MRI and histology validation, revealing their maturation patterns and implications for neurodevelopmental disorders.

Unifying Orientation-Dependent Relaxation and Diffusion Around Axonal Fibers from DTI: Characterizing Fiber-Tract-Specific Anisotropic R2 Profiles of the Corpus Callosum

This paper characterizes orientation-dependent anisotropic R2 profiles in callosal segments using DTI data, showing increases in R2 with b-value and fiber tract position.

Charting the Normal Development of Structural Brain Connectivity in Utero using Diffusion MRI

This study maps fetal brain structural connectivity using diffusion MRI, revealing developmental patterns and introducing a new method for creating age-specific connectome templates.

DTI-ALPS PRIMARILY REFLECTS WHITE MATTER DIFFUSION DISPERSION AND MICROSTRUCTURAL HETEROGENEITY IN NEURODEGENERATION: INSIGHTS FROM MULTI-MODAL MRI

This study investigates DTI-ALPS as a marker of glymphatic flow in neurodegeneration and finds it primarily reflects white matter diffusion dispersion and microstructural heterogeneity rather than glymphatic flow.

Reproducibility of Diffusion, Shape, and Connectivity Metrics Across Scanners: Implications for Multi-Site Tractography

The paper evaluates the reproducibility of diffusion, shape, and connectivity metrics across scanners in multi-site tractography studies and finds shape metrics show the highest reproducibility.

Weakening of subcortical and strengthening of cortical visual pathways across early adolescence

The paper uses longitudinal dMRI data to show that subcortical visual pathways weaken while cortical pathways strengthen during early adolescence, with both linked to faster visual processing.

Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity

The paper shows that white matter tracts are positioned within the cortical hierarchy to support specific cognitive functions and connect regions with greater cognitive diversity.

Comparative Systematic Analysis of Gray Matter BiophysicalModels on a Public Dataset

The paper compares four gray matter biophysical models on a public dataset, finding consistent parameter estimates and highlighting trade-offs in model complexity and robustness.

Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan

This paper introduces an automated DTI-only segmentation method for deep gray matter regions, revealing distinct age-related changes in volume, FA, and MD that differ from volumetric trajectories.

Neonatal brain-age models in full- and preterm infants

This paper develops brain-age models using diffusion MRI data from full- and preterm infants, showing accurate age prediction but limited sensitivity to clinical complications.

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Restriction-weighted q-space trajectory imaging (ResQ): Toward mapping diffusion time effects with tensor-valued diffusion encoding in human prostate cancer xenografts

This paper introduces ResQ, a framework for mapping diffusion time effects in prostate cancer xenografts using tensor-valued diffusion encoding, showing improved parameter accuracy compared to traditional methods.

Replicability of multivariate brain-behaviour associations depends on clinical profile

The paper investigates how sample size and cohort composition affect the replicability of brain-behaviour associations using Canonical Correlation Analysis on UK Biobank data.

Contralesional grey matter volume as an index of macrostructural plasticity in patients with brain tumors

This study shows brain tumors cause structural changes in the opposite hemisphere, detected via PCA and linked to cognitive performance.

Lifespan Normative Modeling of Brain Microstructure

This paper develops a lifespan normative model of brain white matter microstructure using diffusion MRI data from 54,583 individuals, enabling detection of microstructural deviations in diseases like Alzheimer's and 22q11.2 deletion syndrome.

Differential Cerebral White Matter Tract Alterations in Generalized Anxiety Disorder Revealed by Ultra-High Field 7T Diffusion-Weighted Imaging

This study identifies differential white matter tract alterations in generalized anxiety disorder using 7T diffusion imaging, linking them to symptom severity and diagnostic utility.

Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth

The paper identifies a spatiotemporal continuum of structural connectivity development in youth, showing a shift from sensorimotor to association connectivity around age 15 and its links to cognition and psychopathology.

Dynamics of infant white matter maturation from birth to 6 months

This study tracks white matter maturation in infants from birth to 6 months using dense diffusion tensor imaging, finding faster growth rates early on and similar trajectories when adjusted for gestational age.

White matter microstructure and macrostructure brain charts across the human lifespan

The paper develops normative reference charts for white matter microstructure and macrostructure across the lifespan using diffusion MRI data from 50 studies.

Hierarchical Bayesian Modelling Improves Microstructural Parameter Mapping in Diffusion and Exchange MRI Data

This paper introduces a hierarchical Bayesian modelling approach for diffusion and exchange MRI data, showing improved accuracy and noise resilience compared to traditional least-squares methods.

BundleWarp: Enhancing White Matter Tractometry and Morphometry with Precise Neuronal Mapping using Streamline-based Nonlinear Registration

BundleWarp improves white matter tractometry by aligning tracts while preserving anatomical features, enhancing sensitivity to disease-related changes in conditions like Alzheimer's and Parkinson's.

Maturation of Dorsal Association Tracts during Preadolescence Links to Concurrent and Future Cognitive Performance and Transdiagnostic Psychopathology

This study links WM maturation in preadolescence to cognitive performance and future psychiatric disorders using normative models of brain age.

Mathematical Modeling of Neural Stem Cell Migration within Brain using Multi-Fiber Tractography

The paper develops an agent-based model to predict neural stem cell migration in mouse brains using multi-fiber tractography, showing injection location affects distribution and suggesting factors like chemotaxis may be important.

Advancing High-Resolution 7T Diffusion MRI: Evaluating Phase-Encoding Correction Strategies for Distortion Correction from Basic to Four-Way Acquisitions

This study evaluates phase-encoding correction strategies for 7T diffusion MRI to improve geometric accuracy and reproducibility, finding that 4-way PE acquisitions provide the best results.

Investigating the sensitivity of the diffusion MRI signal to magnetization transfer and permeability via Monte-Carlo simulations

This study uses Monte-Carlo simulations to show that permeability and magnetization transfer significantly affect diffusion MRI signal and parameter estimation in cylindrical substrates.

Assessing the Influence of Tractography Methods on Detected White Matter Microstructure in Alzheimer's disease

The paper compares deterministic and probabilistic tractography methods in ADNI data, finding bundle-level differences in white matter microstructure metrics between the two approaches.

Deep-Learning Cortical Registration Guided by Structural and Diffusion MRI and Connectivity

This paper introduces a deep-learning method that improves cortical registration by integrating structural and diffusion MRI data with connectivity features, showing better functional alignment than FreeSurfer.

Evaluating Sample-Size Efficiency and Sensitivity of Tractometry in Alzheimer's Disease

This study evaluates how sample size and resolution affect tractometry's sensitivity and specificity in detecting dementia and amyloid-related effects in Alzheimer's disease.