Invertebrate Immune Response Mechanisms

This study shows that acoels lack conserved immune genes, leading to increased pathogen susceptibility in photosymbiotic species.

This study identifies IbinA and IbinB as regulators of the Toll pathway-mediated immune response in Drosophila, showing distinct roles in infection susceptibility and tissue protection.

The paper investigates the roles of distinct Bomanin peptides from the 55C locus in Drosophila resistance and resilience to infections, finding overlapping and specific functions against different pathogens.

This study uses clodronate liposomes to deplete hemocytes in honey bees, revealing age- and temperature-dependent effects on immune response and survival to bacterial infections.

This paper develops a DiNV model system for studying DNA virus-host interactions in Drosophila by creating cell lines, assays, and infection protocols.

The paper shows piR-bmo-796514 promotes Baculovirus proliferation by downregulating RNF181, which normally inhibits viral entry.

This study examines the transcriptomic response of Saccostrea glomerata to Marteilia sydneyi infection, identifying differentially expressed genes involved in immune responses and potential resistance markers.

This study shows that C. elegans distinguishes pathogen proximity through compound types, activating EV-dependent physiological responses tailored to immediate or anticipated threats.

This study shows that the gut bacterium Rhodococcus rhodnii in Rhodnius prolixus primes the insect's immune system against pathogens, with live bacteria and specific species providing stronger protection than commensals.

This study investigates how Orsay virus infection affects Caenorhabditis elegans larval development and how molting periods influence viral replication.

This study identifies a putative glycan receptor in silkworms based on structural similarity to human LYSMD3 and shows that N-acetylchitohexaose induces immune priming against Pseudomonas aeruginosa infection.

This study shows that NMUR-1 in C. elegans neurons controls energy homeostasis and innate immune specificity through ATP regulation in response to bacterial pathogens.

The paper uses flow cytometry to identify and characterize hemocyte subsets in the American cockroach, finding that granular hemocytes perform key immune functions like phagocytosis and melanization.

This study shows that pUGylation of viral RNAs by RDE-3 in C. elegans promotes antiviral immunity by enabling RdRP-based siRNA production.

The paper investigates how immune responses during wound healing influence the formation of ectopic eyespots on butterfly wings and their pigmentation patterns.

The paper identifies siglec homologs interacting with membrane-bound Hsp70 in B. glabrata snails during S. mansoni infection, suggesting a mechanism for immune evasion.

This study identifies LET-418 as a regulator of intracellular pathogen response in C. elegans intestine by analyzing its target genes and functional effects on immune response genes.

This study shows persistent viral infections in Drosophila melanogaster reduce survival, alter offspring viability, and change behavior, with distinct transcriptional responses across viruses.

This study shows that BMP-dependent fatty acid metabolism in C. elegans enhances survival against bacterial pathogens by promoting desaturation over beta-oxidation.

This study uses Galleria mellonella larvae to test hypotheses about innate immunity's role in bacterial infections and shows bacteriostatic drugs and phages are as effective as bactericidal antibiotics.

This study investigates disease tolerance in Drosophila by exposing it to heat-killed Pseudomonas entomophila, finding that mortality and fecundity reduction depend on exposure duration, sex, and bacterial virulence, with microbiota exacerbating effects.

This study investigates whether Imd-dependent AMPs mediate indirect interactions between gut microbiota and pathogens in a tripartite context, finding that Imd-independent AMPs and microbiota-mediated immune priming influence infection outcomes.

The paper shows infected mosquitoes adjust their diet to reduce parasite load and extend lifespan, suggesting self-medication despite benefits in uninfected individuals.

This study shows that REL2/NF-κB signaling regulates midgut bacterial homeostasis in Anopheles gambiae, with loss of REL2 causing dysbiosis and reduced Plasmodium falciparum prevalence.

The paper examines immune gene expression variability in ant colonies infected by a non-lethal fungus, finding differing responses among workers, queens, and larvae.

This study shows that methylparaben reduces the virulence and transmissibility of Pseudomonas entomophila in Drosophila, highlighting the impact of food preservatives on pathogen behavior.

This paper investigates immune priming in the gut of Tribolium castaneum using RNA sequencing and transmission electron microscopy, showing that priming leads to gut damage, stress response, and gene upregulation that enhances protection against subsequent infection.

This study challenges the assumed antiviral role of Vago genes in Aedes aegypti by showing that VLG-1 has a modest proviral effect during DENV and ZIKV infections.

This study identifies a conserved TNF signaling pathway in Anopheles gambiae that regulates immune cell function and limits Plasmodium parasite survival.

This study shows that microbiota influences sex-specific infection outcomes in mealworm beetles, with females being more susceptible and microbiota depletion reducing this dimorphism.