Invertebrate Immune Response Mechanisms

kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis

This study identifies kri-1/KRIT1 as a regulator that limits skn-1/NRF2 activity to control immune responses and lipid homeostasis in C. elegans, supporting reproductive health.

Differential Gene Expression in the Tropical House Cricket and Its Iridovirus in Healthy versus Diseased Specimens

The paper compares gene expression in healthy and diseased tropical house crickets infected with Cricket iridovirus (CrIV) to identify molecular differences associated with disease symptoms.

Single-cell transcriptomics reveals transcriptional diversity of sea cucumber perivisceral fluid coelomocytes

This study uses scRNA-seq to identify transcriptional diversity in sea cucumber coelomocytes, revealing functional roles and potential progenitor and specialized cell types.

Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia

This study shows that tumor-induced insulin resistance in Drosophila remodels lymph gland hematopoiesis through ImpL2 overexpression and disrupts the Insulin-Wingless signaling axis.

The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

This study identifies Skanda, a serine protease homolog, as a modulator of the Toll-phenoloxidase immune cascade in Drosophila, showing it dampens Hayan activation and contributes to immune response.

The effects of dietary iron supplementation on bacterial infections in Manduca sexta larval hemolymph

This study investigates how dietary iron affects bacterial infections in Manduca sexta larvae, finding that increased iron does not enhance infection severity but has context-dependent effects on survival.

NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System in C. elegans

This study shows that NMR-2, an NMDA receptor subunit in C. elegans, regulates pathogen-induced immune responses through neural circuits involving PMK-1, DAF-16, and HLH-30 pathways.

A TCER-1-siRNA Regulatory Axis Suppresses Antibacterial Innate Immunity in C. elegans

The paper identifies a TCER-1-siRNA regulatory axis that suppresses antibacterial innate immunity in C. elegans by targeting immune effectors like scrm-4.

Sex differences in the regulation and function of cellular immunity in Drosophila

This study investigates sex differences in cellular immunity in Drosophila by analyzing lymph gland structure, gene expression, and immune responses, revealing organ-intrinsic mechanisms and insulin signaling differences.

Host transcriptional signatures associated with disease tolerance and environmental persistence in a mosquito-microsporidian system

The paper examines how parasite life-history strategies affect host gene expression in a mosquito-microsporidian system, identifying distinct host states linked to parasite traits.

Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence

This study shows sex differences in Drosophila intestinal metabolism affect infection outcomes, with males clearing pathogens via antioxidant pathways while females experience higher pathogen virulence.

RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response

The paper identifies CMTR-1 inhibition as a danger signal that activates an ELT-2-dependent immune response in C. elegans, enhancing resistance to Pseudomonas aeruginosa.

Circulating hemocytes continue to proliferate throughout lifespan in Daphnia

The paper shows that circulating hemocytes in Daphnia continue to proliferate throughout their lifespan without evidence of a dedicated hemopoietic stem cell population.

Tracheal terminal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

The paper shows that Drosophila tracheal terminal cells are immune-privileged to maintain Foxo-dependent structural plasticity, as immune activation leads to cell death and structural damage.

Live Imaging of Epithelial Phagocyte Differentiation in the Drosophila Ovary RevealsTransient and Novel Behaviors

The paper uses live imaging to study epithelial cell transformation into phagocytes in Drosophila ovaries, revealing new transient behaviors in phagocytic processes.

Non-Additive Transcriptional Regulation Underpins Additive Survival Trait In Populations Of Drosophila Selected For Increased Post Infection Survival

The paper investigates the genetic and transcriptional basis of post-infection survival in Drosophila selected for increased survival, finding additive genetics but sex-specific transcriptional regulation and functional bottlenecks.

Photoperiod induces sex-specific immune priming in Pyrrhocoris apterus

This study shows that photoperiod induces sex-specific immune priming in linden bugs, with short-day conditions enhancing immune activity in females but not males.

Activation of Toll and IMD pathways in the Drosophila brain following local and systemic bacterial infection

This study shows that bacterial brain infection in Drosophila activates Toll and IMD immune pathways in the brain, with glia as the primary responders, and that these responses persist even after bacterial clearance.

Persistent viral infection in the Drosophila fat body is associated with immune activation at the single-cell level

The paper examines transcriptional changes in Drosophila fat body cells during persistent viral infections using snRNA-seq data, revealing immune pathway activation and transposable element dysregulation.

PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies

This study identifies PGRP-LA as a regulator of peritrophic matrix integrity in tsetse flies, influencing trypanosome infection outcomes by modulating gut barrier function rather than canonical immune signaling.

Functional characterization of specialized immune cells in a cnidarian reveals an ancestral antiviral program

The paper identifies a novel antiviral immune cell type in cnidarians by analyzing gene expression and function in Nematostella vectensis embryos.

Targeted degradation of Drosophila FOG homolog U-shaped mimics macrophage transdifferentiation in S2 cells

The paper shows that degrading U-shaped in Drosophila S2 cells reprograms them to a lamellocyte-like state, mimicking macrophage transdifferentiation.

UVB-Induced Genotoxic Stress Activates the DNA Damage Response and Innate Immune Pathways in Sea Urchin Coelomocytes

This study shows that UVB-induced DNA damage activates DDR and innate immune pathways in sea urchin coelomocytes, revealing conserved mechanisms linking DDR with immunity in invertebrates.

Sex Bias in Iron Sequestration by Transferrin 1 Modulates Sexually-Dimorphic Infection Outcomes in Drosophila melanogaster

This study shows that sex differences in iron sequestration via Transferrin 1 affect infection outcomes in Drosophila, with males being more resistant to Providencia alcalifaciens.

The macroecology of immunity: predominant influence of climate on invertebrate immune response

This study investigates the factors shaping immune response variation in odonates across two biomes, finding that climate, particularly precipitation, has the strongest influence.

Cell-specific responses of Anopheles gambiae fat body to blood feeding and infection at a single nuclei resolution

The paper characterizes the cellular diversity and functional responses of Anopheles gambiae fat body cells to blood feeding and infection at single-cell resolution, identifying specialized roles in immunity and reproduction.

Tachykinin-related peptide signalling is important for the immune response of the mealworm beetle Tenebrio molitor L.

This study investigates the role of tachykinin-related peptide (TRP) signaling in the immune response of Tenebrio molitor, showing that TRP and TRPR genes are downregulated during immune activation and that TRPs modulate antimicrobial peptide expression and phenoloxidase activity.

Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body

The paper investigates spatial patterns of antimicrobial peptide expression in Drosophila larval fat body, finding that these patterns are predetermined and correlate with fluid flow.

Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates

The paper analyzes immune responses in three non-model Drosophilidae species to identify novel antimicrobial peptide candidates and assess immune gene variation.

Loss of immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels

This study shows that acoels lack conserved immune genes, leading to increased pathogen susceptibility in photosymbiotic species.