Neuroscience and Neural Engineering

Direct-print three-dimensional electrodes for large-scale, high-density, and customizable neural interfaces

The paper presents a method for fabricating 3D microelectrode arrays to interface with neural structures, demonstrating high-resolution recording from retinal ganglion cells.

Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation

This paper introduces a method to quantify and compare brain stimulation response shapes using canonical response parameterization, enabling statistical analysis of single-pulse intracranial electrical stimulation data.

Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes

This paper introduces ultraflexible electrodes that enable low-threshold, high-resolution, and chronically stable intracortical microstimulation in mice, with no neuronal degeneration or glial scarring observed.

Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface

This paper develops a soft, infrared neuromodulation device that records electrophysiological signals in rats with minimal tissue response.

Modular, cement-free, customized headpost and connector-chamber implants for macaques

This paper describes long-lasting titanium implants for macaques, with no failures reported and longevity exceeding 9 years.

High-fidelity reproduction of visual signals by electrical stimulation in the central primate retina

This study evaluates the effectiveness of focal electrical stimulation in the central macaque retina to reproduce visual signals, finding higher expected image quality compared to the peripheral retina.

Biophysical modeling of the electric field magnitude and distribution induced by electrical stimulation with intracerebral electrodes

The paper evaluates biophysical models to characterize electric fields from intracranial electrodes in DRE patients, finding that electrode geometry and tissue properties influence field distribution.

Patterned Metal Grids for Flexible and Transparent Neural Microelectrode Arrays

This paper presents patterned metal grid microelectrodes for flexible and transparent neural recordings, showing high transmittance and low impedance suitable for in vivo mouse cerebellum recordings.

Robust online multiband drift estimation in electrophysiology data

This paper introduces DREDge, an algorithm for robust online drift estimation in electrophysiology data, improving scalability and temporal resolution for human and mouse recordings.

A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice

This paper develops a novel micro-ECoG device and surgical technique to record multisensory neural activity from the parietal to temporal cortices in mice.

Human acute microelectrode array recordings with broad cortical access, single-unit resolution and parallel behavioral monitoring

This paper describes the use of microelectrode arrays for acute human cortical recordings with single-unit resolution and behavioral monitoring during surgery.

Biomimetic microstimulation of sensory cortices

This study evaluates how biomimetic microstimulation affects neural activity in sensory cortices, finding that amplitude modulation reduces stimulation-induced depression and improves onset/offset detection.

Responses of cortical neurons to intracortical microstimulation in awake primates

This study examines how cortical neurons in awake primates respond to intracortical microstimulation, revealing complex dynamics including excitatory responses and inhibitory periods.

Semiconducting carbon nanotubes decrease neuronal bursting in a network of rat hippocampal neurons in vitro while increasing intrinsic excitability of single neurons

This study shows that semiconducting carbon nanotubes reduce network bursting but increase single neuron excitability in rat hippocampal neurons.

Pulse trains to percepts: A virtual patient describing the perceptual effects of human visual cortical stimulation

This paper develops a computational model of V1 to predict perceptual outcomes of visual cortical stimulation across multiple studies.

A mesh microelectrode array for non-invasive electrophysiology within neural organoids

This paper introduces a mesh microelectrode array for non-invasive electrophysiology in neural organoids, demonstrating long-term culture and electrical activity recordings.

Real-time in vivo thoracic spinal glutamate sensing reveals spinal hyperactivity during myocardial ischemia

This study uses a glutamate-sensing probe to measure real-time spinal neural activity during myocardial ischemia-reperfusion, revealing increased spinal hyperactivity linked to arrhythmia risk.

A cranial implant for stabilizing whole-cell patch-clamp recordings in behaving rodents

This paper introduces a cranial implant that stabilizes brain movement in behaving rodents, improving the success rate of whole-cell patch-clamp recordings.

Wireless in vivo Recording of Cortical Activity by an Ion-Sensitive Field Effect Transistor

The paper introduces a wireless sensor for in vivo brain activity recording using an ion-sensitive field effect transistor and validates its performance in rodents.

Tracking neural activity from the same cells during the entire adult life of mice

This study develops a stable neural recording method for mice, enabling long-term tracking of single-neuron activity and analysis of aging effects using machine learning.

A wearable platform for closed-loop stimulation and recording of single- neuron and local field potential activity in freely-moving humans

This paper introduces a wearable closed-loop neuromodulation system for recording single-neuron and local field potential activity in freely-moving humans.

Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing

This paper introduces a subdural CMOS optical probe for bidirectional neural interfacing, designed for implantation in primate brains and potential human application.

Multi-area recordings and optogenetics in the awake, behaving marmoset

This paper develops a method to record and optogenetically manipulate neural activity in awake, behaving marmosets, demonstrating its use in recording from V1 and V6 and showing behavioral effects from optogenetic activation in V6.

A thin-film optogenetic visual prosthesis

This paper introduces a thin-film optogenetic visual prosthesis called FlexLED that stimulates retinal ganglion cells to restore vision in a rabbit model of photoreceptor degeneration.

The Effect of Electrical Resonance in Neurons upon the Instability of Electrical Nerve Stimulations

This study introduces a Circuit-Probability theory model to explain how neuronal electrical resonance affects stimulus-induced instability and proposes a method to minimize it.

Significantly reduced inflammatory foreign-body-response to neuroimplants and improved recording performance in young compared to adult rats

This study shows that young rats exhibit reduced inflammatory response and better recording performance with neural implants compared to adult rats.

Gene Expression Changes in Cultured Reactive Rat Astrocyte Models and Comparison to Device-Associated Effects in the Brain

The paper compares gene expression in reactive astrocyte culture models to spatial transcriptomics data from implanted devices in rat brains, identifying shared genes and biomarkers of the foreign body response.

A novel, lightweight drive implant for chronic tetrode recordings in juvenile mice

The paper introduces a lightweight micro-drive implant for chronic electrophysiological recordings in juvenile mice, enabling simultaneous recordings from up to sixteen brain regions during critical developmental stages.

An Open-Source Rodent Chronic EEG Array System with High Density MXene-Based Skull Surface Electrodes

This paper introduces an open-source MXene-based EEG system for chronic rodent recordings, showing it avoids skull surgery and detects mTBI effects on brain activity.

Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in cortex

The paper demonstrates an efficient method to map thalamocortical connectivity in vivo using high-density electrodes in mouse cortex.