Hormonal Regulation and Hypertension

Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension

This study shows fructose-induced salt-sensitive hypertension is linked to abnormal MR activation in the ASDN, increasing ENaC expression and Na+ retention.

Comparison of transcriptional activation by corticosteroids of human MR (Ile-180) and haplotype (Val-180)

This study compares the transcriptional activation of human MR haplotypes (Val-180 vs. Ile-180) by corticosteroids in HEK293 cells using different promoters, finding differences in EC50 and fold-activation.

Rho-ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal via adherens junctions

This study shows that β-Catenin-driven hyperplasia in the adrenal cortex is mediated through Rho-ROCK signaling and Cat-dependent stabilization of adherens junctions.

Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas

This study investigates the role of Substance P and the NK1 receptor in aldosterone-producing adenomas, finding SP-positive nerve fibers and NK1R expression in most APA tissues and SP-induced aldosterone secretion.

Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism

This study establishes an adrenocortical cell model to modulate sodium entry and calcium signaling, revealing its role in aldosterone biosynthesis and PA development.

In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland

This study uses spatial transcriptomics to analyze human adrenal tissue, supporting the centripetal differentiation model and characterizing aldosterone-producing micronodules.