Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo
Joseph Amick, Shamika Bhandarkar, Douglas R. Wilcox, Solenn Boloker, Yi Daniel Lu, Chenghua Gu
STED imaging quantifies luminal versus abluminal localization of blood-brain barrier proteins in vivo; tyrosine motifs drive abluminal sorting of OAT3 and MHC I, and CD31 shifts day to night.
bioRxiv · Sep 22, 2026 · PreprintCell Biology✦ In-depth digest