Barrier Structure and Function Studies

Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction

Simvastatin Preserves Human Microvascular Endothelial Barrier Function Through Mevalonate-Dependent Regulation of RhoB Localization and Activation

This study shows simvastatin preserves endothelial barrier function by modulating RhoB localization and activation through mevalonate-dependent mechanisms during TNF stimulation.

Oncostatin M-driven leak in human endothelial cells with preserved tight junctions

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

Visual experience-driven switch in endothelial metabolic transporters is essential for cerebrovascular maturation

The paper shows that visual experience drives metabolic changes in endothelial cells by switching lactate and glucose transporters, essential for vascular and BBB maturation.

Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation.

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

Brain microvascular endothelial cell dysfunction during Plasmodium infection does not result from astrocyte-derived wingless-related integration site (Wnt)7a deficiency

This study investigates whether astrocyte-derived Wnt7a deficiency contributes to BMEC dysfunction during Plasmodium infection, finding no protective effect of Wnt7a overexpression on cerebral malaria outcomes.

Sex shapes capillary flows and oxygen extraction in the middle-aged mouse brain

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

Breast Cancer-derived PDGFB Remodels the CNS Vascular Niche to Promote Brain, Spinal and Leptomeningeal Metastasis

This study shows that breast cancer-derived PDGFB remodels the CNS vascular niche, promoting brain, spinal, and leptomeningeal metastasis through multiple mechanisms.

Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer's disease

This study identifies CD36-associated vascular changes in Alzheimer's disease and shows CD36's role in regulating endothelial metabolic and immune programs, with potential for targeted therapies.

Cerebral microthrombi promote focal Cav-1-dependent blood-brain barrier impairment, triggering neuroinflammation and neuronal damage after traumatic brain injury

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

Cyclin E/CDK2 deficiency links cell cycle control to intestinal barrier integrity and tight junction regulation

This study shows that Cyclin E/CDK2 deficiency enhances intestinal barrier integrity and tight junction expression in mice, contrary to initial hypotheses.

NE52-QQ57 attenuates post-ischemia protein phosphorylation in the mouse brain

This study shows that NE52-QQ57 reduces post-ischemia protein phosphorylation and crosses the blood-brain barrier in mice.

Ligand-specific endothelial Notch signaling coordinates brain pericyte specification and expansion

This study identifies ligand-specific endothelial Notch signaling as a mechanism coordinating brain pericyte specification and expansion in zebrafish.

Pharmacokinetic properties of Ogerin and its regulation of post-ischemia signaling in mice

This study examines Ogerin's pharmacokinetics in mice and its effect on post-ischemia signaling, finding it most effective in acute hours after injection.

Atomistic Simulation of Blood Brain Barrier Permeability of Propolis Derived Natural Compounds

This study uses atomistic simulations to analyze BBB permeability of two propolis compounds, showing CAPE has favorable permeability while ARC faces significant resistance.

Sex influences gliovascular unit assembly and function in the developing mouse brain

This study compares postnatal maturation of the gliovascular unit in male and female mice, revealing sex-specific differences in angiogenesis, cell composition, and transcriptomic trajectories regulated by oestrogenic signalling.

Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease

The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.

The biophysical interaction network that couples zona occludens-1 to membrane proteins at tight junctions

This study maps the biophysical interaction network of ZO-1 with tight junction transmembrane proteins, revealing how they couple intracellular and extracellular signaling through binding mechanisms and phase separation.

The Alzheimer's Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells

This study shows that CD2AP regulates endothelial barrier function and immune cell transmigration, linking it to Alzheimer's disease.

Low-Density Lipoprotein Cholesterol and Cerebral Pericyte Dysfunction in Acute Ischemic Stroke: Clinical and Experimental Evidence

This study links LDL-C to cerebral pericyte dysfunction in acute ischemic stroke through clinical and experimental evidence, showing oxidative stress and type-I interferon signaling changes.

APOE Genotype and Fluid Biomarkers of Blood-Brain Barrier Integrity: A Systematic Review and Meta-Analysis

This study reviews and analyzes the association between APOE genotype and fluid biomarkers of blood-brain barrier integrity, finding significant associations for APOE ε2 but not ε4.

Barrier Function of the Vero E6 Cell Monolayer

This study demonstrates that Vero E6 cells form functional barrier layers with measurable TEER and permeability, comparable to endothelial models, and are sensitive to calcium chelation.

Axons organize into micro-tracts around the cortical vasculature

The paper examines the organization of axons around cortical vasculature in mice, finding that axons form micro-tracts around capillaries, which may facilitate neurovascular coupling.

Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestration

The paper identifies paraspeckles as mediators of microbial insult-induced neurovascular remodeling through CYR61-FGF2 signaling via RBM14 sequestration, showing therapeutic potential.

Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo

STED imaging quantifies luminal versus abluminal localization of blood-brain barrier proteins in vivo; tyrosine motifs drive abluminal sorting of OAT3 and MHC I, and CD31 shifts day to night.

Controlled Blood-Brain Barrier Modulation by a High-Affinity Claudin-5 Peptide Binder

The paper designs a high-affinity CLDN5 peptide binder, ST9, that induces reversible, size-controlled BBB openings without altering CLDN5 expression or proteomic profile.

Lab-on-a-chip device integrating a human stem cell-based blood-brain barrier model with neural organoids for translational research

This paper develops a lab-on-a-chip system integrating a human BBB model with neural organoids to study BBB function and nanoparticle transport, showing BBB integrity and nanoparticle entry into neural tissue.

Brain defence by the extracellular matrix protein Cochlin

This study identifies Cochlin as an extracellular matrix protein produced in brain barriers that enhances immune defence against bacterial infection in zebrafish.

APOE-ϵ4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

Reperfusion reshapes the temporal evolution of neurovascular injury after ischemic stroke

This study investigates how reperfusion affects neurovascular injury after ischemic stroke, finding that while it reduces acute damage, it leads to chronic vascular dysfunction.