Psychedelics and Drug Studies

This study compares neural dynamics changes in schizophrenia and psychedelic-induced states using M/EEG data, finding distinct patterns in information transfer and Bayesian inference alterations.

This study examines psilocybin's effects on thalamic functional organization and connectivity using a novel ICA approach, revealing spatially constrained changes in intrathalamic nuclei and thalamocortical connections.

This study evaluates the behavioral and neurochemical effects of ten novel N-Benzyl-2-phenylethylamine derivatives in adult zebrafish, identifying compounds with hallucinogenic-like and anxiolytic properties.

This study shows that LSD and psilocybin reduce hierarchical cortical organization by flattening connectivity gradients, supporting a mechanistic model of the psychedelic state.

This paper analyzes 6,850 hallucinogenic experiences to link drug-induced consciousness changes to brain receptor distributions using natural language and gene expression data.

The paper integrates transcriptomics with large-scale cortical modeling to simulate LSD's effects on brain function, revealing serotonin-2A receptor-mediated changes in cortical connectivity.

This study shows that psilocin levels and subjective drug intensity correlate with changes in brain network integrity and segregation after psilocybin administration.

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.

This study examines changes in resting-state functional connectivity after a single psilocybin dose in healthy individuals, finding decreased executive control network connectivity at one-week and a link to increased mindfulness at three-months.

This study investigates the neural correlates of the shamanic state of consciousness using EEG in practitioners and controls, finding distinct brain activity patterns compared to psychedelic-induced states.

This study examines how psilocybin dose affects subjective experiences in humans using meta-regression on standardized questionnaires.

This paper uses a whole-brain computational model to simulate perturbations under LSD and finds increased dynamical complexity and recovery time, with strongest effects in resting state networks.

This study investigates the electrophysiological effects of ibogaine in rats, finding increased gamma oscillation power with reduced coherence and complexity, suggesting REM sleep traits in the psychedelic state.

This study investigates how sub-anaesthetic ketamine affects EEG signal diversity and finds increased spontaneous signal diversity correlates with altered consciousness.

This paper develops a mechanistic model explaining how 5HT2A-R activation increases neural entropy in the brain, showing non-uniform regional effects linked to anatomical connectivity.

This study examines how psilocybin affects functional connectivity in mice, revealing distinct changes in serotonin and dopamine-related networks.

This study investigates how DMT alters cortical travelling waves during a resting state, finding reduced backward and increased forward waves, supporting a model of altered precision-weighting of priors.

This paper shows that LSD and psilocybin increase the fractal dimension of brain activity in both spatial and temporal domains, suggesting a shift toward criticality in neural systems.

This study examines changes in directed functional connectivity during the psychedelic state using MEG and finds a general decrease in directed connectivity for LSD, psilocybin, and low-dose ketamine.

This study identifies distinct neural mechanisms for MDMA's prosocial effects and rewarding properties in mice, showing serotonin transporter and dopaminergic signaling play separate roles.

This study examines how IV DMT affects EEG brain activity, finding reduced alpha/beta power and increased signal diversity, with delta/theta activity correlating with peak subjective experience.

This paper explores 5-MeO-DMT as a potential neurochemical tool for studying cognition and creativity through interdisciplinary evidence.

This study shows that LSD-induced changes in brain connectivity are mediated by the 5-HT2A receptor, as demonstrated by the blocking effect of a 5-HT2A antagonist.

This study quantitatively examines the cognitive effects of microdosing psychedelics on creativity and problem-solving in healthy adults, finding improvements in convergent and divergent thinking but no change in fluid intelligence.

The paper introduces a VR platform using deep convolutional neural networks and panoramic videos to simulate visual hallucinations, showing it can replicate psychedelic-like experiences without causing temporal distortion.

This study investigates proteomic changes in human cerebral organoids treated with 5-MeO-DMT, identifying 934 differentially expressed proteins and suggesting anti-inflammatory and synaptic modulation effects.