Nuclear Receptors and Signaling

Modulation of Nur77-DNA Interactions by the Glucocorticoid Receptor

This study investigates how the glucocorticoid receptor and its ligand dexamethasone modulate Nur77-DNA interactions using single-molecule assays, revealing distinct effects on binding dynamics and affinity.

Nurr1 orchestrates claustrum development and functionality

This study identifies Nurr1 as a critical transcription factor for claustrum development and function, showing its role in neuronal positioning and behavior regulation.

Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

This paper investigates the activation mechanism of NR4A-RXR heterodimers using a diverse RXR ligand set, revealing both classical and non-classical activation pathways.

Nurr1 modulation mediates neuroprotective effects of statins

This study identifies Nurr1 modulation by statins as a mechanism underlying their neuroprotective effects, showing statins affect Nurr1 activity and induce neuroprotective mechanisms.

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)

The paper identifies 5-chloroindole as a stable analog of DHI that activates Nurr1 and promotes dopamine-related gene transcription.

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.