Nuclear Receptors and Signaling

Janus kinase 2 regulates Nurr1 protein stability in dopaminergic neurons of the aging midbrain

This study identifies JAK2 as a regulator of Nurr1 protein stability in aging dopaminergic neurons, showing JAK2 enhances Nurr1 activity through physical interaction rather than phosphorylation.

Modulation of Nur77-DNA Interactions by the Glucocorticoid Receptor

This study investigates how the glucocorticoid receptor and its ligand dexamethasone modulate Nur77-DNA interactions using single-molecule assays, revealing distinct effects on binding dynamics and affinity.

The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor

This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.

Nurr1 orchestrates claustrum development and functionality

This study identifies Nurr1 as a critical transcription factor for claustrum development and function, showing its role in neuronal positioning and behavior regulation.

Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

This paper investigates the activation mechanism of NR4A-RXR heterodimers using a diverse RXR ligand set, revealing both classical and non-classical activation pathways.

Nurr1 modulation mediates neuroprotective effects of statins

This study identifies Nurr1 modulation by statins as a mechanism underlying their neuroprotective effects, showing statins affect Nurr1 activity and induce neuroprotective mechanisms.

The nuclear receptor NR4A1 restrains neutrophil granulocyte mediated brain damage in cerebral ischemia

This study shows NR4A1 reduces brain damage after ischemic stroke by limiting neutrophil activation and recruitment, with Cytosporone-B improving outcomes.

Premature MeCP2 Expression Disturbs the Subtype Specification of Midbrain Dopamine Neurons.

This study shows that premature MeCP2 expression disrupts midbrain dopamine neuron subtype specification by interfering with NURR1 transactivation and TET1-mediated demethylation in NPCs.

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)

The paper identifies 5-chloroindole as a stable analog of DHI that activates Nurr1 and promotes dopamine-related gene transcription.

Bioinformatics approach reveals Nur77-regulated genes common to the central nervous and immune systems

The paper identifies Nur77-regulated genes shared between the central nervous system and immune system using public databases.

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.