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Increased EV yield and bioactivity of matrix-bound nanovesicles compared to conditioned culture medium-derived extracellular vesicles

This study compares EV yields and bioactivity between liquid-EVs and MBVs from MSCs, finding MBVs have significantly higher yields and are more effective in wound repair.

Multi-Angle Lateral-View Breast Tissue Classification in Thermographic Images Using Deep Reinforcement Learning and Statistical Shape Modelling

This paper develops a hybrid method combining deep reinforcement learning and statistical shape modeling to improve breast tissue classification in thermographic images, achieving 74.1% accuracy.

Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation

This study creates mesaconate-based polyester nanoparticles that show different immunomodulatory effects in macrophages and improve survival in endotoxemia.

Substrate chemistry in cancer bioelectronics: phenotype-dependent cell-electrode coupling and motility

This study examines how electrode coatings affect cell-electrode coupling and motility in different breast epithelial phenotypes, finding that coating effects vary with cell type.

Collagen V Presented at the Cell-Substrate Interface Mimics Substrate Stiffening to Enhance Fibroblast Traction, Adhesion Turnover, and Persistent Migration

This study shows that presenting collagen V at a cell-substrate interface enhances fibroblast traction, adhesion turnover, and migration, mimicking the effects of substrate stiffening.

Novel 3D Mature Osteocyte Perfusion Platform Reveals Subtype-Dependent and Radiation-Sensitive Disruption of Mechanotransduction by Breast Cancer Secretomes

This study shows that breast cancer subtype and radiation affect osteocyte mechanosensing, with ER+ tumors being more sensitive to radiation-induced secretome changes.

Spheroid surgery: a first-generation micromanipulation platform for extracting viable cell clusters from the outer layers of hydrogel-embedded spheroids

This paper introduces a micromanipulation platform to extract viable cell clusters from hydrogel-embedded 3D spheroids without disrupting the parent structure.

Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses

Cellular Traction and Morphological Adaptation to Cell-Scale Stiffness Gradients on Length-Encoded Micropillar Arrays

This paper develops a micropillar array platform to study how cancer cells respond to mechanical stiffness gradients at the cell scale, finding biphasic pillar displacement and increased traction forces with stiffness.

Recombinant spore-displayed enzymes for cellulose hydrolysis: dual-enzyme spores versus mixed single-enzyme spores

This study compares dual-enzyme spore display with mixed single-enzyme spores for cellulose hydrolysis, finding that mixing single-enzyme spores yields higher glucose production.

Do protein representations encode variant function? Diagnosing residue-level protein attributions via embedding-space gradients

This paper evaluates residue-level attributions in protein language models using synthetic fitness landscapes and identifies interventions that improve attribution accuracy.

kinGEMs: A Robust and Scalable Framework for Resource-Constraint Models through Stochastic Tuning of Deep Learning-Predicted Kinetic Parameters

This paper introduces kinGEMs, a framework that integrates deep learning-predicted kinetic parameters into genome-scale models to improve metabolic modeling accuracy and scalability.

Anatomically Programmable and Optically Tunable 3D-Bioprinted Tumor-Mimicking Phantoms for Quantitative Nanofluorophore Benchmarking

This paper develops 3D-bioprinted tumor-mimicking phantoms to benchmark nanofluorophores under surgical conditions, showing their ability to evaluate fluorescence properties and guide tumor resection.

Recombinant surface display of lichenase on Bacillus subtilis spores to improve animal feed digestibility

This study displays a lichenase on Bacillus subtilis spores, enhancing its thermal stability and feed substrate hydrolysis efficiency compared to the free enzyme.

Frequency modulated semi-continuous wave Doppler ultrasound: A novel method for the detection of scatterer velocity and range using wearable ultrasound instrumentation

This paper introduces frequency modulated semi-continuous wave Doppler ultrasound as a novel technique for measuring scatterer velocity and range using wearable ultrasound systems.

Genetically programmable molecular framework for constructing precision recombinant human ECM mimics

This paper introduces a genetically programmable hydrogel platform to create precision recombinant human ECM mimics with tunable mechanical and biological properties.

AutoMod: A Software Tool for High-Accuracy Design of Curved DNA Origami Nanostructures

AutoMod improves DNA origami design accuracy by reducing shape deviation in curved structures through semi-automated sequence generation and benchmarking.

Fibronectin Tethering as a Shear-thinning Bio-Annealing Strategy for Granular Hydrogels

This paper introduces FN-MAP, a fibronectin-coated microparticle scaffold that combines mechanical stability and bioactivity, showing improved cell response and translational potential in 3D bioprinting and wound healing.

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast conditioning to define distinct drivers of fibrotic progression

This study uses 3D lung models to show that environmental stiffness has the strongest effect on fibroblast phenotype and that both matrix composition and stiffness influence gene expression in fibrotic disease.

Molecular Engineering of Silk via Fatty Acid Esterification for Water-Stable, Anti-fouling, Biocompatible, Implantable Materials

This study modifies silk fibroin with fatty acid esterification to create water-stable, anti-fouling, biocompatible materials for implantable applications.