Discover, rate, and discuss biology preprints.

This study shows that TGFβ1 and RGD peptides work together to drive aggressive behavior in prostate cancer cells using a 3D hydrogel model.

This study develops tissue-specific high cell-density bioinks for 3D bioprinting, enabling the formation of multi-phase tissues with controlled architecture.

This paper introduces a plug-and-play TEER system integrated into an organ-on-chip platform for real-time barrier dynamics monitoring, showing improved sensitivity over conventional methods.

The paper develops an MRI-free virtual neuronavigation method for TMS using scalp measurements and a standard head model, achieving 2.75 mm mean error in simulated tests.

The paper introduces a human colon microphysiological system that replicates the 3D topography and matrix stiffness of the colon using hydrogels and microfluidic control, enabling long-term culture and imaging of colonic epithelial cells.

This paper develops hybrid bioinks and an embedding bioprinting technique to create a multilayered artery model that mimics native blood vessel structure and supports cell viability.

This study compares decellularized human amniotic membrane grafts with ePTFE grafts in pigs, finding DAM grafts have better patency, less inflammation, and reduced neointimal hyperplasia in small-diameter vascular surgeries.

This study shows that ECM maturation and cytoskeletal tension determine the strain threshold for stretch-induced calcium signaling in human tendon cells.

The paper tests numerical methods for reconstructing cerebrospinal fluid flow from contrast-enhanced MRI data, finding that methods perform well in idealized settings but struggle with patient-specific data.

This study simulates lateral pinch grasp using different muscle groups to identify alternatives to FPL tendon transfer that reduce joint hyperflexion and deviation.

This paper develops a bioengineered skin equivalent using electrospun PCL functionalized with a bioactive peptide to treat severe burn injuries, showing improved wound closure and skin regeneration in mice.

This paper uses causality analysis to identify phosphatidylcholine as a key factor enhancing plasma proteome profiling through protein corona composition changes on nanoparticles.

This study develops hypoimmunogenic hPSC-derived cardiac organoids that evade immune rejection and repair damaged hearts in animal models.

The paper develops a multilayer vascular graft with a polymeric coil to improve kink resistance while maintaining compliance, using advanced manufacturing and finite element modeling to optimize biomechanical performance.

This study uses base editing to correct the SCN8A R1872W mutation in mice, reducing seizures and improving survival and comorbidities.

This study shows that cerebellum-targeted tFUS at 10kHz modulates hippocampal neural activity through cerebellum cortex, not deep nuclei, via altered neurodynamic interactions.

This paper introduces a GPU-based cardiac electrophysiology solver that enables fast and scalable simulations, demonstrating significant speedup and integration into a digital twin pipeline.

This paper develops a paper-based LAMP assay for detecting H5 subtype avian influenza virus with a detection limit of 500 copies per reaction, offering a low-cost, user-friendly diagnostic tool for resource-limited settings.

This paper explores DNA six-way junction conformations, identifies preferred structural isomers, and demonstrates their use in creating a 2D square lattice for DNA nanotechnology.

The paper designs a post-transcriptional BANDPASS filter using the CsrA-uxuB interaction in E. coli, showing concentration-dependent regulation of uxuB mRNA.