Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- BioengineeringbioRxivPreprint
Stabilizing gas in aqueous liquids with metal-organic frameworks for persistent acoustic transduction
Wang Wenliang, Weilong He, Miranda V. Walter…·Huiliang Wang
This paper demonstrates the stabilization of gas in aqueous environments using metal-organic frameworks to enable persistent acoustic transduction for long-term ultrasound-biological interfacing.
DOI 10.64898/2026.10.27.762357 - BioengineeringbioRxivPreprint
A Proof-of-Concept Study on Attached Spirulina Cultivation Under Microgravity and Partial Gravity Aboard the ISS
Takashi Inada, Motoshi Kamada, Hayato Ohkuma…·Takanori Hoshino
This study evaluates Spirulina cultivation under different gravity conditions on the ISS, showing feasible growth without detachment or medium issues.
DOI 10.64898/2026.10.27.762075 - BioengineeringbioRxivPreprint
Ultrasonic local anesthetic uncaging enables noninvasive, targeted, and transient knock-out of brain function
Payton J. Martinez, Yun Xiang, Kancha Sinha Roy…·Raag D. Airan
This paper demonstrates SonoRopi, a noninvasive method using ultrasound to transiently inhibit brain function in mice and rats.
- BioengineeringbioRxivPreprint
Intelligent SEEQPI enables reconstruction of inhibitory neuronal nuclei and dry-mass mapping deep in the living mouse brain
Jiaqi Yao, Jinhua Lyu, Naichen Shi, Xi Chen
This paper introduces SEEQPI, a label-free imaging technique, to reconstruct inhibitory neuronal nuclei and estimate dry-mass density in deep brain regions of living mice.
- BioengineeringbioRxivPreprint
Ratio-preserving super-resolution FLIM for quantitative live-cell lifetime imaging
Chenyang Li, Linglong Li, Yiwen Cheng…·Liangyi Chen
This paper introduces SIM-fdFLIM, a super-resolution FLIM method that preserves ratio accuracy and enables high-speed, high-resolution live-cell lifetime imaging.
DOI 10.64898/2026.10.25.761648 - BioengineeringbioRxivPreprint
Non-destructive tree volume estimation using mobile laser scanning: Impact of the tree shape on measurement error.
Justin Holvoet, Philippe Lejeune, Jérôme Perin…·Gauthier Ligot
This study evaluates the accuracy of mobile laser scanning for tree volume estimation, finding that tree shape has a limited impact on measurement error compared to scanning conditions and forest structure.
DOI 10.64898/2026.08.11.744158 - BioengineeringbioRxivPreprint
In situ loading of biologics on and tissue redirection of circulating extracellular vesicles with an anchoring nanobody
Gang Han, Li Zhong, Huanan Yu…·尹海芳
This paper demonstrates that NEV3, an EV-anchoring nanobody, enables in situ loading of proteins onto circulating extracellular vesicles and redirects them to specific tissues in vivo.
DOI 10.64898/2026.10.26.761597 - BioengineeringbioRxivPreprint
Multiscale, Survey-and-Target Optical Super-Resolution Histology
Kidan Tadesse, Oliver S. Lee, Hajun Yoo…·Shu Jia
This paper introduces MOSH, a multiscale optical super-resolution histology platform that enhances resolution while maintaining tissue-scale context and throughput.
DOI 10.64898/2026.10.26.762070 - BioengineeringbioRxivPreprint
Spatial engineering of posterior signaling centers in cerebral organoids via controlled morphogen exposure within hydrogels
Harrison Jeong, Hajime Ozaki, Yuan‐Chen Tsai…·Herdeline Ann M. Ardoña
This paper introduces a hydrogel platform to spatially engineer posterior signaling centers in cerebral organoids through controlled morphogen exposure, improving spatial organization and cellular diversity.
DOI 10.64898/2026.06.02.729607 - BioengineeringbioRxivPreprint
CAR-macrophage immunotherapy targeting fibroblast-like synoviocytes ameliorates inflammatory and degenerative arthritis
Yangli Xu, Zhuqian Wang, Duoli Xie…·Chao Liang
This study develops CAR-M2-FAP and CAR-M2-NCL therapies targeting FLS in RA and OA, showing reduced inflammation and joint damage in mouse models.
DOI 10.64898/2026.10.25.761728 - BioengineeringbioRxivPreprint
Effect of Clover versus Zipping on Annular Geometry and Dynamics in Tricuspid Edge-to-Edge Repair
Magda Piekarska, Tomasz Stącel, Collin E. Haese…·Tomasz A. Timek
This study compares Clover and Zipping techniques in tricuspid edge-to-edge repair, finding that Clover reduces septal-lateral annular diameter more effectively.
DOI 10.64898/2026.10.25.761672 - BioengineeringbioRxivPreprint
Topographical features enhance DNA tetrahedron biostability
Sarah Youssef, Lauren Anderson, Mengyao Zheng, Arun Richard Chandrasekaran
This study shows that adding hairpins to DNA tetrahedra increases their nuclease resistance, enhancing biostability through sequence-specific stabilization.
DOI 10.64898/2026.10.27.762189 - BioengineeringbioRxivPreprint
Transient matrix remodeling during direct cell-fate reprogramming enables self-assembly of dense neuronal niches
Kerstin Laurin, Mette Habekost, Fredrik Nilsson…·Janko Kajtez
This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.
DOI 10.64898/2026.10.27.762125 - BioengineeringbioRxivPreprint
Quanta microscopy enables fluorescence imaging at the native bit-plane rate
Jooyeong Yun, Keyi Han, Aleksandra Janusz…·Shu Jia
Quanta microscopy enables high-speed fluorescence imaging at the native bit-plane rate by reconstructing multibit images from sparse photon-detection maps.
DOI 10.64898/2026.10.26.761986 - BioengineeringbioRxivPreprint
Personalised prediction of anomalous bone regeneration in multiple myeloma patients
Fiona Gibson, Rebecca E. Andrews, Michelle Anne Lawson…·Stefaan W. Verbruggen
This study develops computational models to predict bone regeneration in multiple myeloma patients using patient data and genomics, showing rapid strengthening not fully explained by known mechanisms.
DOI 10.64898/2026.10.26.761863 - BioengineeringbioRxivPreprint
Megalin-mediated deterministic pseudotransduction in proximal tubules fundamentally challenges current understanding of AAV kidney transduction
Anusha Sairavi, Ranjan Das, Lena Li…·Hiroyuki Nakai
The paper shows that AAV-mediated gene delivery to proximal tubules is not direct but relies on megalin-mediated uptake of reporter proteins from other organs, challenging current understanding.
DOI 10.64898/2026.10.26.761697 - BioengineeringbioRxivPreprint
Ultrasonic Detection of Venous Gas Emboli and Tissue Gas in Rodents: Toward Imaging Biomarkers for Decompression Stress
Joshua B. Currens, Katherine M. Eltz, Rani S. Sellers…·Virginie Papadopoulou
This study uses ultrasound to detect venous gas emboli and tissue gas in rats after decompression, finding a correlation between gas emboli severity and decompression risk.
- BioengineeringbioRxivPreprint
Single-vector AAV delivery of En-ISPmu1 and donor DNA for in vivo targeted genome integration
Alessio Conci, Ilaria Bonuzzi, Matteo Ciciani…·Anna Cereseto
The paper describes the development of En-ISPmu1, a modified TnpB nuclease, and demonstrates its ability to achieve targeted genome integration in mouse liver with a single AAV vector.
DOI 10.64898/2026.10.26.761871 - BioengineeringbioRxivPreprint
Three-Dimensional Fluid-Structure Interaction Reveals Trade-offs Among Oxygen Delivery, Shear, and Washout in Pediatric Roller-Pump Cardiopulmonary Bypass
Yunpeng Tu, Yi‐Ting Yeh, Alex De Lecea…·Christina L. Greene
This study uses a 3D fluid-structure interaction model to show that pediatric roller-pump settings with similar oxygen delivery can result in different shear and washout environments, suggesting the need for joint evaluation of these metrics.
DOI 10.64898/2026.10.26.761989