Discover, rate, and discuss biology preprints.

The paper investigates the structural plasticity of the HflK/C complex in bacteria, showing that both open and closed conformations are critical for adaptation to aminoglycoside stress.

The paper analyzes sarcomere-length recordings in neonatal rat cardiomyocytes to show that hyperthermal sarcomeric oscillations (HSOs) exhibit a constrained neighboring-sarcomere phase topology and that the mean HSO amplitude can be described by the product of local amplitude and synchrony.

This study uses single-molecule magnetic tweezers to analyze CFTR folding defects and shows pharmacological correctors reshape the folding energy landscape by catalyzing transitions.

This study maps condensate dielectric permittivity using fluorescence and reveals that membrane interactions depend on permittivity contrast rather than absolute permittivity.

The paper uses single-molecule techniques to study tRNA structural dynamics before and during interaction with the pseudouridine synthase Pus4, revealing conformational changes and remodeling effects.

This paper introduces a coarse-grained modeling framework to analyze how mutations affect protein conformational dynamics and identifies mutation-sensitive regions.

BIOPOINT is a particle-based model that simulates nuclear mechanics and cell-ECM interactions using experimentally derived parameters, validated against experimental data.

This study shows that optimizing the number of filaments per aster in cytoskeletal networks enhances mechanical strength and rigidity, as revealed by computational simulations and percolation theory.

This study shows that residue burial information can predict protein backbone conformation more efficiently than other representations, suggesting core identity is a better encoding for fold prediction.

The paper designs lanthanide-binding mini-proteins with enhanced luminescence using non-canonical amino acids and computational methods.

This study shows sodium ions regulate GPCR activation by altering allosteric coupling networks and hydration patterns in the dopamine D2 receptor.

This paper introduces COMET, a drift correction method for SMLM that improves resolution and temporal precision, and demonstrates its effectiveness across multiple SMLM techniques.

The paper investigates the determinants of metal import and specificity in the bacterial transporter DraNramp by analyzing sequence variants and their effects on Mn2+ and Mg2+ import.

This paper develops a method to determine site-specific O-acetylation in RG-I oligomers using deuterated acetyl groups and tandem mass spectrometry.

This study uses computational models to analyze the topology of PCV2 viral genomes, revealing that different internal arrangements can produce similar external structures but vary in stability and function.

This paper demonstrates fiber optical parametric amplification to boost low-photon-flux microscopy signals, achieving higher sensitivity and bandwidth than conventional detectors.

This study links brain strain metrics from strain tensor imaging to vascular and tissue properties using mixed-effects models.

This study identifies sequence-dependent rules for collagen contraction driven by water-mediated structural rearrangements during dehydration.

This paper introduces a reaction-diffusion compartment model to study pattern dynamics under mass conservation, showing that stripe patterns can be stabilized by parameter changes not observed in the original system.

PySteMoDA provides an automated tool for analyzing steered molecular dynamics simulations, improving accuracy and accessibility in computational biochemistry and biophysics.