Discover, rate, and discuss biology preprints.

This study identifies genetic loci and cellular mechanisms underlying flag leaf size variation in barley using a multi-parent population and fine mapping.

The paper uses Kozak sequence libraries to modulate protein abundance and function, showing their impact on viral infection rates and identifying disease-associated variants.

This study shows that germline loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and hypothermia, mediated by NHR-49/PPAR.

The paper shows that two RDRs in Paramecium are required to convert exogenous dsRNA into siRNAs for RNAi, contrasting with known functions in other organisms.

The paper uses poly-microsatellite markers to analyze genetic diversity and complexity of malaria infections in two Kenyan regions, finding higher complexity in Busia compared to Kilifi.

This study identifies genomic regions associated with temperature stress responses in Zymoseptoria tritici using QTL mapping and candidate gene analysis.

The paper identifies Seo1p as a high-affinity transporter for gamma-Glu-met in yeast and fungi, showing its specificity and role in peptide uptake.

This study assesses genetic variability in hot pepper landraces and an improved genotype in Ethiopia, finding significant phenotypic and genotypic variation with recommendations for high-yielding accessions.

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

The paper uses long-read RNA sequencing to analyze CLN3 transcription complexity and the impact of a common 1-kb deletion in juvenile CLN3 disease, revealing multiple transcripts and isoforms.

The paper identifies genetic variants associated with antibody responses to infectious diseases in Tanzanian dairy cattle using genome-wide association studies.

The paper uses medaka fish to study genetic and environmental interactions in heart rate, identifying QTLs and validating genes, while showing limitations of GWAS in capturing complex genetic effects.

This study identifies genetic variants underlying seven Mendelian traits in pea, revealing new alleles and gene mutations for traits previously poorly understood.

JointPRS improves genetic risk prediction for non-European populations by integrating genetic correlation and multi-population data without individual-level tuning data.

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

The paper develops an AI-enhanced CRISPR prime editing framework for correcting TOR1A mutations in dystonia, showing strong predictive performance and identifying key factors influencing editing efficiency.

The paper introduces CRISPR-CISH, a chromogenic in situ DNA detection method that uses CRISPR/dCas9 to generate target-specific signals visible under bright-field microscopes.

This study shows that experimental GALT mRNA therapy improves motor function in a mouse model of Classic Galactosemia.

The paper identifies a hypomorphic MYRF variant causing partial loss of function in the RPE, with two novel splicing variants linked to isolated nanophthalmos.