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This paper introduces a method using genetic relatedness matrices to control genetic confounding in observational studies, showing improved performance over existing approaches in smaller datasets.

The paper uses deep mutational screening to analyze SPOP variants, identifying loss-of-function variants enriched in prostate cancer and revealing their structural and genetic characteristics.

The paper identifies a common genetic basis for G. pallida virulence against GpaVvrn resistance across Western Europe and develops a tool to assess virulence in the field.

The study analyzes genetic diversity in two small populations of Colobus vellerosus in Benin using mitochondrial markers, finding very low diversity due to a potential genetic bottleneck.

The paper identifies a rapid adaptive increase in AMY1 gene copy number in Indigenous Peruvian Andeans linked to potato domestication.

This study uses adult polygenic g scores to track cognitive development in 10,000 children, showing increasing predictive power over time.

HLAfreq is a Python package that downloads, combines, and analyzes HLA allele frequency data from multiple sources to improve estimates and visualize population differences.

The paper characterizes the SCON system in Cdh12 conditional knockout mice, revealing unintended splicing changes that affect mRNA expression.

The paper introduces CRI-SPA-Map, a genetic mapping strategy in yeast that identifies causal genetic variants for phenotypic differences without genotyping.

The paper investigates BLTP1's role in neocortical lamination by analyzing patients and mouse models, finding lipid transport defects cause structural brain abnormalities.

CleanFinder is a scalable framework for analyzing genome editing outcomes, enabling detailed genotyping and comparison across diverse edit types and contexts.

The paper investigates functional and localization differences among orthologs of the Drosophila melanogaster essential gene gdrd, finding that some orthologs can rescue fertility while others cannot due to structural and physicochemical differences.

This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.

This paper optimizes wheat breeding programs using an evolutionary algorithm, achieving higher genetic gain and diversity while maintaining a fixed budget.

The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.

The paper identifies suppressors that limit the spread of the selfish Segregation Distorter in Drosophila melanogaster by analyzing genetic variation across 90 strains.

The paper identifies a genomic signature, G-tract-AG motifs, that regulates transcriptome integrity and diversity through repression of AG usage and SNV-induced splicing activation.

The paper analyzes the evolutionary development of regulatory elements in the human bicistronic gene SMIM45, identifying diverse mechanisms for the formation of super-enhancers and super-silencers over millions of years.

The paper shows Sir proteins impede but do not prevent access to silent chromatin in yeast, using DNA methylation rates as a measure.