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The paper links trans-pQTLs to protein-protein interactions and GWAS loci, identifying therapeutic targets in autoimmune diseases.

This paper identifies and functionally validates the scar-6 lncRNA locus, showing it regulates prozb expression and modulates coagulation and vascular function in zebrafish through epigenetic mechanisms.

This study identifies the roles of argonaute proteins in RNAi inheritance in C. elegans, showing HRDE-1 is required for silencing while WAGO-3 is essential for inheritance.

This study analyzes genetic diversity and phylogenetic relationships of Common Teal in Kashmir wetlands, revealing shared haplotypes with European populations and highlighting the region's ecological importance for migratory birds.

This study identifies a lncRNA, aal1, that extends lifespan in fission yeast by reducing ribosome content and protein translation, with similar effects observed in Drosophila.

The paper evaluates base editing efficiency for USH2A mutations using in vitro screening and a mouse model, showing high correction rates and comparing methods.

The paper identifies regionally enriched rare deleterious exonic variants in the UK and Ireland using exome sequencing data, highlighting potential implications for genetic screening and counseling.

The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.

This study identifies gene expression changes in Aedes aegypti males during swarming using whole-head RNA-seq, finding reduced housekeeping functions and increased cytoskeleton and neuronal connectivity remodeling.

The paper identifies ivory, a conserved lncRNA, as the color pattern gene at the cortex locus in buckeye butterflies, showing how cis-regulatory elements of ivory influence seasonal color variation.

BEATRICE identifies causal variants from GWAS summary data using a Bayesian framework, outperforming baselines in coverage and finding the APOEε2 allele in Alzheimer's disease.

The paper introduces SBAT, a method for joint testing of rare variant burden scores, showing it is well calibrated and outperforms existing tests in some scenarios.

This study identifies 13 novel genetic associations and confirms 17 existing ones between SNPs and neonatal metabolites using genome-wide association analysis of maternal low-pass genomes.

This study identifies extensive β-defensin gene copy number variation in cattle, particularly DEFB103, and links it to fertility-related traits.

The paper evaluates current methods for predicting plant variety performance in the UK Recommended List system and suggests improving statistical models to better account for genetic relationships and environmental interactions.

MOIRE, a Bayesian R package, jointly infers allele frequencies, multiplicity of infection (MOI) and within-host relatedness from SNP or polyallelic malaria genotypes, yielding a panel-portable effective MOI.

This study shows that UBR-1 deficiency in C. elegans causes ivermectin resistance by disrupting glutamate signaling and GluCl function.

The paper identifies FIGL1 as a key factor limiting non crossover events in Arabidopsis thaliana meiosis through tetrad sequencing analysis.

The paper investigates how rDNA copy number variation affects yeast fitness under different environmental conditions and finds that higher copy numbers improve fitness in stress conditions.

The paper investigates the combined effects of SCN5A enhancer variants on gene expression and demonstrates their additive regulatory impact in vitro and in vivo.