Discover, rate, and discuss biology preprints.

The paper introduces a new alignment method, MPGA, to better handle tandem repeats and replication slippage in DNA sequences, showing improved measures of substitution rates and transition-to-transversion ratios.

MADDD-seq detects DNA damage and mutations simultaneously in yeast using a modified double barcoding sequencing approach, revealing repair kinetics and mutagenesis over 24 hours.

This study identifies H2BE as a widely expressed H2B variant that enhances chromatin accessibility in neurons, promoting synaptic gene expression and long-term memory.

JASPER improves multitrait genetic association analysis in structured samples, finding more significant gene expression associations and pleiotropic effects.

The paper argues that causal gene identification methods should be evaluated using statistical techniques instead of gold-standard gene sets due to their incompleteness and labeling biases.

The paper identifies issues with the chimeric formula for quantifying epistasis, showing it can lead to incorrect biological interpretations in higher-order interactions.

The paper shows that SLC30A10 deficiency leads to increased manganese absorption via iron transporters SLC11A2 and SLC40A1, contributing to manganese excess and disease.

The paper introduces a new formalism for representing ancestral recombination graphs that generalizes classical approaches and supports modern computational methods.

This study identifies TaNADPO as a key gene for wheat resistance to Bipolaris sorokiniana through GWAS, RNA sequencing, and transgenic experiments.

The paper uses ChIP-ISO to analyze sequence features affecting FOXA1 binding and finds that AP-1 influences FOXA1 binding specificity and context-dependent binding.

This study uses whole-genome sequencing and machine learning to reconstruct demographic history and gene-flow patterns among African populations, finding that tree-like histories with gene-flow pulses better explain genetic diversity than continuous gene-flow.

The paper examines the association between physical performance and telomere length in Mexican older adults, finding shorter telomeres in those with lower physical performance.

This study introduces a deep learning framework, FIND, to better classify genetic variants by their deleteriousness and trait-modulating effects, showing improved performance over existing methods.

The paper shows that reduced synMuv B gene activity in C. elegans enhances RNA interference against viral infection.

MalKinID identifies malaria parasite genealogical relationships using IBD proportions and segment distributions, showing high accuracy in outcrossed importations but reduced performance in inbreeding scenarios.

This study uses simulations to show that migration increases repeated genetic adaptation despite pleiotropy, suggesting repeatability is more common in local adaptation than global adaptation.

This study identifies genes regulating CNS morphology in Drosophila through a genetic screen, revealing a role for senseless-2 in surface glia.

The paper identifies non-coding DNA variations affecting P53 and cMYC-driven diseases by analyzing co-occupancy of these transcription factors and correlating DNA variations with gene expression changes.

The paper identifies peri-centrosomal localization of siRNAs in C. elegans using NRDE-3 as a reporter, showing dependence on 22G siRNAs and centrosomal components.

The paper proposes a nonlinear mixed-effects model to analyze genetic and environmental effects on soybean growth using simulated and experimental data.