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This study identifies genetic factors influencing susceptibility to chills from art and music using large-scale genetic data from 15,606 individuals.

This study uses a Drosophila model to show that CFTR loss reduces cholinergic signaling, which contributes to gut pathologies, and that restoring cholinergic signaling can rescue these phenotypes.

This paper proposes a method to correct for multiple testing in IBD mapping for case-control studies, identifies six genome-wide significant AD risk loci, and shows positive selection can confound results.

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

This study identifies 263 genes associated with key wheat traits in Henan Province through GWAS and selective sweep analysis, revealing breeding advances and candidate genes for future improvement.

The paper classifies ABCC6 genetic variants using structural genomics to identify pathogenic mechanisms and reclassify variants of uncertain significance.

This study identifies DNA methylation instability in blood cells linked to aging and disease, showing age-related instability and associations with cardiovascular disease and cancer.

PyMSQ provides a fast Python package for computing Mendelian sampling variance, covariance, and haplotype-based similarity in genomic selection, enhancing haplotype diversity management.

The paper demonstrates the use of IR-LEGO to knock down genes in specific Drosophila genital structures, revealing its potential for manipulating transcript abundance in small cell groups during development.

This study shows BICC1 interacts with PKD1 and PKD2, exacerbating ADPKD severity through RNA metabolism, using animal models, genetic studies, and human cohorts.

This paper develops a quantitative genetic model to analyze how indirect genetic effects and genomic imprinting influence genetic variance under random and assortative mating.

This study constructs genetic maps, develops markers, and identifies candidate genes for powdery mildew resistance in Malus baccata 'Jackii' using SNP and SSR data from an F1 population.

The paper uses a CRISPR screen in Xenopus to identify FLNB as a novel gene associated with congenital heart disease and ciliopathies.

This study identifies haploblocks associated with rust resistance in wheat and develops a selection index to improve breeding for durable resistance.

This paper develops an enviromic framework to predict tree performance and guide clonal deployment in Eucalyptus spp., achieving higher accuracy than traditional GxE models.

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

The paper identifies vmeQTLs for blood DNA methylation variance in MZ twins, showing gene-environment interactions and cell-type effects relevant to immune disease.

The paper constructs a large-scale LD and genotype imputation reference panel using whole-genome sequencing data from 2,680 Indian participants, improving imputation accuracy and polygenic risk score performance.

The paper identifies platform-dependent effects of APOL1 variants on plasma levels measured by different proteomic technologies.

This study uses whole-genome sequencing in 672,976 individuals to show rare and common variants converge in genetic associations for anthropometric traits, with ultra-rare variants explaining less than 10% of heritability.