Discover, rate, and discuss biology preprints.

This study evaluates how genetic variation and chromosomal inversions affect CRISPR-Cas9 gene drive homing in Anopheles gambiae strains, finding no significant reduction in homing despite target site heterogeneity.

This study identifies CG11000 as an astrocyte-enriched gene in Drosophila, showing its role in development, locomotion, and lifespan through single-cell RNA sequencing and functional assays.

The paper identifies and validates activation domains in non-transcription factor proteins across Arabidopsis and yeast, discovering novel coactivators and universal genetic parts for synthetic biology.

The paper reveals that CTCF binding at TAD boundaries is modular and clustered, challenging existing models of loop extrusion blocking and highlighting a complex code for TAD structure and function.

The paper identifies Stb15, a lectin receptor-like kinase gene conferring resistance to Septoria tritici blotch in wheat, through GWAS and functional validation.

This study uses machine learning and functional weights to identify rare variants associated with AUDIT-P, finding significant associations in ADH1C and THRA genes.

The paper uses CRISPR screening guided by machine learning to identify essential non-coding hubs in epigenetically quiescent regions, revealing their distinct 3D contacts and phenotypic effects on cell growth and chromatin structure.

The paper compares ACE2 gene expression between African-American and non-African-American COVID-19 patients, finding downregulation in African-Americans associated with lower disease severity.

This study compares gene drive spread characteristics in continuous space models, finding differences in wave speed and vulnerability to fitness costs and resistance.

The paper analyzes inflammation biomarkers using whole-genome sequencing from the TOPMed consortium, identifying both single-variant and rare variant associations with inflammatory traits.

The paper tests for polygenic epistasis in biobank-scale data and finds 16 trait-loci pairs with strong evidence of interaction effects.

The paper investigates how mutations interact in diploid organisms, showing that epistasis and dominance are common, context-dependent, and change with system complexity and conditions.

The paper identifies shared genetic architecture across different types of clonal hematopoiesis and finds that overlapping mutations increase hematological malignancy risk.

This study identifies BARD1 germline variants associated with reduced BARD1 expression and DNA repair defects in neuroblastoma, showing haploinsufficiency and increased genomic instability.

The paper integrates genetic fine-mapping with multi-omics data to identify candidate effector genes and new drug targets for hypertension.

The paper reanalyzes hybridization frequency between European smooth and palmate newts using SNPs, finding low hybridization rates and suggesting microsatellites overestimate introgression.

This study differentiates WISP3-deficient and sufficient hPSCs into articular cartilage-like tissues, revealing transcriptomic and cellular differences linked to PPAC pathogenesis.

This study shows that interpreting TWAS results as evidence of genetic relationships between gene expression and phenotypes leads to inflated type 1 errors and unreliable conclusions.

The paper identifies the core gene set of Saccharomyces cerevisiae by analyzing 94 strains, revealing 5885 core genes and highlighting annotation issues and genomic variability.

The paper identifies an AluYb8 insertion in the 3'UTR of TMEM106B associated with increased dementia risk and shows it is shared across risk alleles.