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From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference

This paper evaluates the impact of retaining close relatives on demographic inference using IBD-based methods and finds that retaining relatives reduces bias in Ne estimates.

Persistent selection on size explains micro- and macroevolutionary alignments in fly wings

The paper reanalyzes data to show wing size in Drosophila is the primary selection target, explaining micro- and macroevolutionary patterns through a single-axis selection model.

Likelihood Ratios Given Activity-Level Propositions for DNA Transfer Evidence: Theoretical Foundations of the HaloGen Framework (Part I)

This paper establishes the theoretical basis of HaloGen, a hierarchical Bayesian framework for evaluating DNA evidence under competing activity-level propositions using likelihood ratios.

Clinical and primary cell evidence reveals complex CFTR function-phenotype relationships

The paper integrates clinical and primary cell data to show the CFTR function-phenotype relationship is logarithmic, not linear, with greater phenotypic gains at lower baseline function.

A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I

This study shows that a mammalian-specific domain of MSH5 is essential for converting licensed DSB repair intermediates to designated class I crossovers during meiosis.

Likelihood Ratios Given Activity-Level Propositions for DNA Transfer Evidence: Practical Implementation and Simulation Studies Using the HaloGen Engine (Part II)

This paper implements and evaluates the HaloGen framework for calculating activity-level likelihood ratios in DNA transfer evidence, showing how case context affects results.

Widespread genetic testing control inherited polycystic kidney disease in cats

This study examines the impact of PKD1 genetic testing on feline populations, finding a significant decrease in the PKD1 variant frequency and no changes in genetic structure or inbreeding.

CFTR function in nasal airway cells from symptomatic and asymptomatic CF heterozygotes

This study measures CFTR function in nasal airway cells from CF heterozygotes and controls, finding reduced CFTR activity in heterozygotes regardless of symptoms.

Functional Profiling of 2,193 ASS1 Missense Variants: Insights into Variant Pathogenicity and Epistatic Interactions in Citrullinemia Type I

The paper functionally profiles 2193 ASS1 missense variants to determine their pathogenicity and epistatic interactions in Citrullinemia Type I.

Homozygosity destabilizes phenotypic robustness in clonal Drosophila mercatorum

The paper shows that homozygosity in Drosophila mercatorum reduces phenotypic robustness, leading to increased developmental instability and reduced survival under stress.

Lethal Plague Outbreaks in Lake Baikal Hunter-gatherers 5500 Years Ago

This study identifies the oldest known plague strains in Lake Baikal hunter-gatherers 5500 years ago, showing early outbreaks were lethal and challenged the idea that agriculture was necessary for plague epidemics.

Chromatin Assembly Factor 1 is required for normal structure and function of facultative heterochromatin in Neurospora crassa

This study shows that CAF-1 is necessary for proper structure and function of facultative heterochromatin in Neurospora crassa, working with PRC2 to silence transcription.

Wolbachia-induced cytoplasmic incompatibility produces heritable chromatin modifications that suppress position-effect variegation

The paper shows Wolbachia-induced chromatin modifications suppress position-effect variegation in Drosophila, persisting into adulthood and not fully reversed by CifA.

Meiotic pairing through barcode-like satellite DNA repeats

The paper demonstrates that satellite DNA barcodes facilitate meiotic pairing in Drosophila by showing that repeat mismatches disrupt pairing and that pairing defects correlate with oocyte death.

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

Differential genetic resistance identified in Parastagonospora nodorum and Pyrenophora tritici-repentis-wheat pathosystems

The paper identifies genetic resistance mechanisms in wheat against two fungal pathogens, showing distinct resistance mechanisms for Septoria nodorum blotch and tan spot.

LsBADH1 is responsible for sweet fragrance in lettuce (Lactuca sativa L.) through 2-acetyl-1-pyrroline biosynthesis

The paper identifies LsBADH1 as the gene responsible for 2-acetyl-1-pyrroline (2AP) biosynthesis, which causes the sweet fragrance in lettuce, and shows that a premature stop codon in LsBADH1 increases 2AP levels.

Xist expression in male Peromyscus leucopus is associated with restricted chromatin repression and incomplete X-to-autosome dosage compensation

This study identifies robust Xist expression in male Peromyscus leucopus somatic cells, showing gene-selective repression rather than global X-chromosome inactivation.

Faroese Whole Genomes Provide Insight into Ancestry and Recent Selection

This study analyzes whole genome sequencing data from the Faroe Islands to explore ancestry, genetic diversity, and signals of recent selection in a North Atlantic founder population.

Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae.

This study shows that cohesin sumoylation is required for subtelomeric gene repression in yeast, independent of its role in sister chromatid cohesion.