Discover, rate, and discuss biology papers.

This paper develops a toolkit using AcrIIA4 to suppress, subtract, and segregate Cas9 activity in Drosophila for more precise CRISPR applications.

The paper analyzes the distribution of simple repeat lengths across mammalian genomes and shows that long repeats are abundant due to mutational dynamics, not natural selection.

This study shows that a human BSX variant in mice disrupts circadian behavior and food anticipation but preserves lifespan and metabolic homeostasis.

The paper develops a joint statistical model to show that higher Mapuche genetic ancestry and accelerating BMI trajectories independently increase the likelihood of early menarche in admixed girls.

The paper describes the development of a congenic C57BL/6 rd1 mouse model to improve retinal degeneration research by reducing genetic variability.

The paper links GWAS-associated genes to single-cell RNA-seq data to identify cell types associated with 14 brain phenotypes, confirming and discovering new cell-type-disease associations.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

The paper investigates how natural genetic variation in Arabidopsis thaliana affects centromere-proximal crossover frequency and segregation distortion during meiosis.

The paper compares Rad51 and Dmc1 recombinases using structural and functional analyses to show differences in their interfacial amino acids and evolutionary trajectories.

The paper shows that DNA methylation of EdnRB regulates color change in cichlid fish by affecting pigment aggregation in response to visual environment.

This study uses QTL mapping and a foundation model for phenotyping to identify genetic loci associated with grapevine cluster compactness and yield traits.

The paper compares epigenetic aging estimates between the 450K and EPICv2 arrays, finding that some clocks are affected by missing probes, but overall correlations remain strong.

This study uses Trio-GCTA to analyze direct and indirect genetic effects on educational achievement using parent-offspring trios, finding genetic contributions and gene-environment correlations.

This study uses long-read sequencing to resolve the complex CES1 genomic locus, identifying new haplotypes and structural variants, and highlighting issues with short-read sequencing artifacts.

The paper catalogs endogenously tagged proteins in C. elegans, identifies gaps in coverage, and provides a database with tools for designing knock-in experiments.

This paper develops a tripartite AAV system to deliver the large EYS gene using recombination, showing successful in vitro and in vivo expression of full-length EYS protein.

This study profiles DNA methylation across metamorphosis in Nasonia vitripennis, finding variable methylation levels and site-specific patterns linked to developmental processes but no clear connection to gene expression.

This paper quantifies how polygenic scores are affected by ancestry stratification using a theoretical framework and applies it to UK Biobank data.

The paper identifies allele-specific chromatin structures in imprinted domains and shows their interaction with cis-acting long non-coding RNAs to regulate imprinted gene expression.