Discover, rate, and discuss biology preprints.

This study benchmarks molecular dating accuracy for single gene trees, identifying factors like alignment length, rate heterogeneity, and selection pressure that affect divergence time estimation.

The paper introduces clam, a tool that efficiently estimates nucleotide diversity and divergence using variant-only VCFs and callable loci, improving computational performance and storage.

The paper introduces a dynamic clustering approach for genomics cohorts based on trait-specific genomic signals, revealing patterns beyond predefined racial or continental categories.

The paper identifies sex-specific DNA methylation differences in blood samples from individuals with mild cognitive impairment and Alzheimer's disease, showing distinct epigenetic regulation by sex.

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

The paper reports the genome of a symbiotic bacterium from Haematomyzus elephantis, showing it has a highly reduced genome and retains B vitamin synthesis pathways, similar to other sucking lice symbionts.

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

Mobius, a transformer model using DNA methylation data, accurately distinguishes ME/CFS, Long COVID, and healthy controls with high performance.

This study uses RNA-sequencing to analyze how calorie restriction and rapamycin affect gene expression in yeast, revealing their synergistic effect in extending postmitotic cell lifespan.

The paper presents a method to estimate genome size using mapping-based approaches and demonstrates its application across various organisms.

MedakaBase provides a centralized platform for genomic resources and analysis tools for medaka fish, including gene models and omics data for multiple Oryzias species.

This study uses ancient DNA data to show genetic continuity in the Northern Iranian Plateau from the Copper Age to the Sassanid Empire, with some western genetic influence.

ATaRVa improves TR genotyping accuracy and efficiency using long-read sequencing, excels in low coverage datasets, and includes motif decomposition and methylation profiling.

DiffInvex identifies chemotherapy resistance genes by analyzing 10,000 cancer genomes, finding known and novel genes under conditional selection for specific therapies.

The paper identifies a noncanonical role for KZFPs in restricting TE-derived regulatory elements to maintain cell-type identity, independent of TRIM28.

The paper curates a collection of transcriptome datasets from viral respiratory inoculation and vaccination studies to enable reanalysis of transcriptional responses in blood and nasal samples.

The paper introduces HiddenFoot, a probabilistic model to infer TF, nucleosome, and Pol II occupancy from single-molecule data, revealing binding dynamics and heterogeneity in mouse, Drosophila, and human cells.