Discover, rate, and discuss biology preprints.

The paper develops a spatial DNA methylation profiling method called SmC-seq and applies it to study DNA methylation dynamics in mouse embryos and decidua after implantation, revealing spatial heterogeneity and functional roles of hypomethylated regions in nutrient provision.

The paper identifies synchronized codon usage evolution between functionally related genes across bacterial genomes, revealing new functional associations.

The paper identifies mitochondrial DNA variants in Kenyan populations that may influence cancer treatment responses, suggesting their potential relevance for precision oncology.

The paper identifies a TET2-AGO2 regulatory axis that links epigenetic remodeling to myeloid commitment and leukemia progression.

The paper identifies distinct genetic mechanisms for early (nuclear) and late (cellular) RNA eQTL by comparing their genomic localization and functional effects across tissues.

The paper develops and validates a microsatellite panel for Gyrodactylus salaris to enable individual-level genetic analysis and population studies.

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

This study identifies recurrent LINE-1 exonization events in NSCLC that generate new transcript isoforms, contributing to transcriptome diversity without affecting gene expression levels.

The paper presents a chromosome-level genome assembly for the invasive erythrina gall wasp, Quadrastichus erythrinae, and its endosymbiont Wolbachia pipientis, revealing genomic features and evolutionary insights.

The paper compares immune responses to viral and bacterial stimuli in three bony fish species using transcriptomic analysis, identifying conserved gene expression patterns and pathways.

This study compares machine learning and conventional models for genomic prediction of fertility traits in Holstein heifers using low-coverage sequencing data, finding that KRR_GRM improves accuracy over traditional methods when using only genomic data.

This study identifies genomic regions and haplotypes associated with resistance to fusarium wilt and sterility mosaic disease in pigeonpea using GWAS and KASP validation.

The paper reviews methods for estimating inbreeding, relatedness, and population structure and proposes five recommendations for improving allele-sharing statistics.

The paper shows that Ded1 in yeast primarily stimulates translation by unwinding 5' UTR structures, not by suppressing upstream ORF translation.

The paper examines genomic differentiation between marine and freshwater stickleback populations in Atlantic Canada, identifying regions consistently differentiated despite varying demographic histories.

This study identifies large genomic rearrangements and copy number variants in HCT116 cell line samples using Oxford Nanopore sequencing and compares common and unique variants across samples.

SPIN uses AlphaFold3 to predict host-pathogen protein interactions in plant pathogens, improving prediction reliability with a multi-metric scoring framework.

This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.