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The paper introduces QuEST immunofluorescence microscopy to quantify TCR signalosome stoichiometries in human T cells, revealing a 1:1 ZAP-70:TCR ratio and CD28 recruitment independent of CD80/CD86.

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.

This study shows that pregravid obesity in rhesus macaques alters fetal immune development, leading to immune dysregulation and increased disease susceptibility in offspring.

This paper reports four novel VHHs against VEEV E2 protein selected using computational and biochemical strategies, showing they can bind and sequester viral particles, acting as viral sponges.

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

This study uses single-cell and spatial transcriptomics to analyze immune responses in non-human primates after retinal gene therapy, identifying persistent immune infiltration and cytokine-driven inflammation.

This study identifies CREB/CRTC2 as a regulator of GPR65 in Th17 cells, showing its role in metabolic fitness and pathogenic function through RNA-seq and chromatin immunoprecipitation.

This paper develops a mathematical model to evaluate nano-drug efficacy against leishmaniasis by simulating macrophage-parasite interactions and comparing iron oxide and citric acid-coated iron oxide nanoparticles.

This study shows that misoprostol reduces C. difficile infection severity by decreasing neutrophil infiltration and G-CSF levels, highlighting innate immune modulation as a therapeutic strategy.

This paper develops an optimized protocol to amplify allogeneic Vγ9Vδ2 T cells for adoptive cell transfer, showing they maintain antitumor activity and a pro-inflammatory profile.

The paper identifies cooperative roles of Foxp3 and BATF in directing cis-regulatory programs and gene expression for Treg cell differentiation.

This study identifies glutaminolysis as a therapeutic target to suppress emergency myelopoiesis by targeting glutaminase in hematopoietic stem and progenitor cells.

DynaKiller-Scan characterizes single-cell killing dynamics and molecular signatures in cytotoxic lymphocytes, revealing differences in kinetics and cytokine responses between CD4+ and CD8+ CAR-T cells.

This study identifies a conserved metabolic-oxidative pathway causing immune cell cryo-vulnerability and shows that targeted pretreatments can significantly improve post-thaw survival and function.

This study identifies K61-mediated K48 ubiquitination and proteasome degradation of porcine STING as a species-specific mechanism regulating antiviral signaling.

This paper develops a DNA-tethering method to rapidly assemble bispecific lipid nanoparticles for targeted T cell mRNA delivery, showing improved targeting and transfection compared to single-targeted LNPs.

This study shows TACI regulates MZ B cell development through the PI3K-AKT pathway and FOXO1 inhibition, not B cell survival.

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

This study shows that endothelial cells with a STINGV154M mutation cause persistent skin inflammation after UVB exposure, linking STING activation to impaired myeloid cell recruitment and delayed inflammation resolution.