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This study isolates and characterizes monoclonal antibodies against Toscana virus's Gc glycoprotein, identifying cross-reactive antibodies that protect against Rift Valley Fever Virus.

The paper identifies the Bhlhe40-S100a4 cascade as a key regulator of cancer cell mitochondrial transfer from T cells, offering a target for immunotherapy.

This study shows IL-27 reduces cell-surface LDLR in macrophages and limits VSV-G-pseudotyped HIV infection through receptor downregulation and post-entry mechanisms.

This study examines how mutations in the N-terminal domain of SARS-CoV-2 Spike affect antigenic properties and immune escape, finding that structural flexibility and loss of heme-metabolite interaction reduce antibody neutralization.

This study identifies T lymphocyte regulatory cytokines as predictors of frailty in older adults using machine learning and serum cytokine analysis.

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

This study shows that Pseudomonas aeruginosa CF isolate DH1137 reduces inflammasome activation and IL-1β release in alveolar macrophages under hypoxia, potentially aiding immune evasion in cystic fibrosis.

The paper identifies viral E3 ligase activity as a conserved trigger of NLRP1 inflammasome activation, expanding effector-triggered immunity against viral pathogens.

This study identifies the CD44-CD206 axis as a glycoimmune checkpoint that promotes immune exclusion in bladder tumours with immature O-glycosylation.

The paper shows that in chronic SIV infection, viral RNA is mainly found in B-cell follicles of lymphatic tissues, leading to structural damage and sustained virus-host interactions.

This paper identifies a redox-gated phagocytic rheostat in neutrophils by analyzing phosphoproteomic and functional responses to bacterial exposure.

The paper finds that early pregnancy SARS2 vaccination is associated with increased detection of T cell maternal microchimerism in cord blood.

This study analyzes T cell subsets, clonality, and trajectories in psoriasis using single-cell RNA and TCR sequencing, revealing tissue-specific and shared features of the T-cell repertoire.

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This study tracks the temporal changes in the tumor microenvironment after nanobody-based CAR-T therapy, revealing dynamic gene expression shifts and identifying potential therapeutic targets.

This study uses genetic biosensors to visualize calcium signaling dynamics in macrophages, revealing mechanosensitivity and the effects of Piezo1 channel ablation.

This study engineers T cells to respond to G-CSF instead of IL-2, enabling effective melanoma treatment without lymphodepletion or IL-2.

This paper identifies an IFNγ-CXCL9-CXCR3 axis linking T cell recruitment to skeletal muscle remodelling in human physical frailty, showing its association with fibrosis and potential therapeutic targets.

The paper shows that inhibiting NF-κB/p65 increases galactose-deficient IgA1 production by reducing C1GALT1 expression and altering B cell subpopulations in IgAN patients.

This study shows that the ITK-SLP-76 Y173 axis is essential for TCR signal persistence and thymic development, as its disruption reduces thymocyte cellularity and alters CD4/CD8 ratios.