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StainStyleSampler clusters and samples stain styles from whole slide images to improve machine learning robustness across different staining appearances.

Whole-genome sequencing and geolocation tracking indicate that high pathogenicity avian influenza H5N1 reached Tristan skuas on remote Gough Island via sub-Antarctic marine networks linked to South Georgia rather than Africa.

This study shows SGLT2 inhibitors reduce mTORC1 hyperactivity and proximal tubulopathy in cystinosis models by altering lysosomal metabolism, independent of cystine clearance.

This study identifies Pita2a as a major gene conferring broad-spectrum neck blast resistance in rice using GWAS and functional validation.

This paper characterizes neural network learning dynamics in digital pathology by measuring activation structure, weight evolution, and entropy changes during training.

This paper evaluates spectral models in histopathology tasks and finds they underperform CNN baselines but offer interpretability benefits.

This paper develops a deep learning model to predict molecular alterations in never-smoker lung adenocarcinomas from histological images, achieving high accuracy for most features.

This study evaluates EGCG's protective effects against enzymatic stromal degradation in goat and sheep corneas and validates these animals as ex vivo models for keratoconus research.

This study identifies a size-dependent trajectory of islet remodeling in T2D, showing medium and large islets correlate with glycemic failure while small islets show compensatory responses.

This study identifies PRDM16 as a critical regulator of chondrogenesis and chondrocyte identity in the knee joint through DNA binding and histone modification.

This study examines the morphological effects of formic acid treatment on mouse brain tissues, finding it compromises tissue structure and varies by brain region, without worsening effects in neurodegenerated tissues.

This study develops a lethal mouse model to study Rio Negro virus pathogenesis, revealing systemic and neurological effects, immune system disruption, and neuroinflammation.

The paper shows that voluntary running maintains gene expression corrections from AAV gene therapy in mdx mice, indicating physical exercise does not negatively affect therapy outcomes.

This study identifies ADAMTS7's role in promoting atherosclerosis by enhancing smooth muscle cell foam cell formation via an AP-1/PU.1/CD36 pathway.

The paper surveys banana viruses in Malawi, identifies BBTV, BanMMV, and BSV species, and links their prevalence to specific Musa germplasm groups.

This study shows that gut microbiota changes and colonic adaptation occur before hyperphagia in a rat model of short bowel syndrome.

This study identifies lipid remodeling patterns in acute kidney injury, linking specific lipid signatures to injury and protection mechanisms.

This study validates the use of kidney biopsy transport medium for rapid gene profiling to enable same-day molecular diagnosis of kidney disease.

The paper investigates how hypertension affects signaling dynamics in specific renal cell types using single-cell RNA sequencing and NicheNet analysis.

This study identifies circulating FABP4 as a mediator of adipocyte-hepatocyte lipid crosstalk in obesity and shows that targeting it with a monoclonal antibody reduces hepatic steatosis in mouse models.