Discover, rate, and discuss biology preprints.

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

This study identifies increased soluble platelet activation markers and PAI-1 in moderate COVID-19, suggesting early coagulation system activation before severe disease.

The paper reinterprets cystic liver lesions in cetaceans as Budd-Chiari-like syndrome caused by gas bubbles and pre-existing vascular disorders, not acoustic trauma.

This study investigates ZIKV persistence in male macaque reproductive tissues, finding prolonged viral presence in germ and epithelial cells and potential impacts on fertility.

The paper introduces a class-controlled copy-paste augmentation method to address class imbalance in histopathology cell segmentation, improving metrics for underrepresented classes.

This study evaluates the diagnostic accuracy and reproducibility of human experts and a deep learning algorithm for scoring exercise-induced pulmonary hemorrhage in horses using bronchoalveolar lavage fluid.

This paper develops a LAG-3 immunohistochemistry assay for melanoma, demonstrating high specificity, sensitivity, and reproducibility for clinical use.

This study detects NNV (RGNNV genotype) in imported grouper fry in Thailand, identifies its pathogenic effects, and confirms its presence in CNS and retina.

This study validates a photonic chip-based super-resolution microscopy platform for high-throughput multimodal histopathological analysis of cryopreserved tissue samples.

This study examines ZIKV infection in Olive baboons during early and mid-gestation, finding fetal CNS pathology by term gestation despite resolved viremia.

This study tests carbamazepine's effect on bone structure and strength in OI mice and controls, finding no benefit in OI mice but growth impairment in controls.

This study uses multimodal imaging and machine learning to analyze bone tissue, achieving >90% accuracy in distinguishing cancer-related diagnostic categories.

This study evaluates the consistency of LAG-3 IHC assays using the 17B4 antibody across three staining platforms, finding high correlation and agreement.

This paper develops a deep learning model to quantify plasma cell percentages in CD138-stained bone marrow samples, achieving high accuracy comparable to pathologists.

This study compares the biological effects of orthovoltage X-rays and 137Cs γ-rays in mouse models, finding that lower-energy X-rays cause more severe hematopoietic and intestinal injury at equivalent physical doses.

This study shows that inhibiting RUNX1 improves heart function after myocardial infarction by preserving contractility and mitochondrial function.

This study identifies circulating Stx2-containing microvesicles in a rat HUS model and suggests they may serve as a biomarker for HUS progression.

This study investigates the role of glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins TcdA and TcdB during infection, showing both contribute to disease with distinct pathological outcomes.