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This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.

This study compares the acute effects of three exercise intensities on subcutaneous adipose tissue transcriptome in regular exercisers, finding intensity-specific gene expression changes and common pathways involved in cardiometabolic health.

This study shows that deleting Dbc1 in adipocytes does not cause healthy obesity but reveals a role for Dbc1 in inflammation during obesity.

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

This paper introduces SMPFO, a method combining fluorescence assays and proteome profiling to study skeletal muscle, revealing reduced myofiber subtype divergence in nemaline myopathy.

The paper updates demographic data showing that human lifespans continue to increase globally, supporting Oeppen and Vaupel's original hypothesis over Olshansky's claim of a lifespan ceiling.

The paper identifies CFTR High Expresser cells in rat small intestine as pH-sensing neuropod cells and links them to CF disease pathogenesis.

This study uses in vivo 2-photon imaging and photoactivatable fluorescent labeling to show that mitochondrial dynamics in skeletal muscle are slower in vivo than previously thought, with age-related differences and exercise-induced increases.

This study identifies age-related vacuolation in multi-ciliated cells of the distal mouse oviduct, linked to reduced blood flow and unique cellular identity in the infundibulum and ampulla.

This study investigates the effects of menaquinone-9 (MK9) supplementation on bone health in mice, finding no significant impact on bone tissue quality or mineral density despite MK9 serving as a precursor to MK4 in bone.

This study optimizes Void Spot Assay (VSA) visualization techniques for rats using bright field, ultraviolet, and ninhydrin spray, finding that ninhydrin spray provides the best results for urine detection.

This study examines if neodymium exposure reduces the hypoxic ventilatory response in fathead minnows, finding a 31% decrease in the response with no detectable gill accumulation.

This study shows that latent Toxoplasma gondii infection reduces visceral nociception in mice via peripheral opioid receptor signaling, suggesting a potential negative link with abdominal pain in humans.

This study identifies the secretome of cardiac fibroblasts in healthy and infarcted mouse hearts, revealing dynamic paracrine factors and potential biomarkers or therapeutic targets.

This study shows that Npas4 in POMC neurons regulates food intake during obesity by modulating inhibitory GABA-A receptor expression and neuronal activity.

This study investigates whether diapause and glycerol upregulation are linked in Manduca sexta and finds they are not, as diapausing pupae have lower glycerol levels than non-diapausing pupae.

This study examines how beta and gamma neural activity differs between unimanual and bimanual motor tasks and how these patterns change with learning.

This paper develops standardized, low-cost methods for rearing Manduca sexta larvae in a lab setting, facilitating their use in physiological and pathogen studies.