Discover, rate, and discuss biology preprints.

The paper measures solute diffusion in cardiac myocytes and finds that diffusion is significantly restricted, likely due to myofilament and mitochondrial networks, with porin channels allowing faster diffusion.

This study shows that preserving mitochondrial membrane potential during dietary restriction extends lifespan in C. elegans by maintaining mitochondrial function and nutrient sensing.

This study examines muscle function during diagonal style roller skiing, finding uncoupling of muscle and joint behavior with changes in speed and incline.

This study shows that GDF15 mediates renal cell plasticity in response to potassium depletion by regulating intercalated cell numbers and K+ retention.

This study investigates how SUMOylation of NaV1.5 affects cardiac sodium current and electrophysiology, finding it increases peak INa without altering INa,L and may influence arrhythmic risk.

This study examines how Arctic char adapt metabolically to cyclic hypoxia over 30 days, showing they maintain growth and energy reserves despite initial metabolic changes.

This paper applies machine learning and virtual reality tools to improve the volumetric analysis of arterial lesions in animal models of cardiovascular disease.

This study identifies GDF15 as a mediator of improved metabolic health and thermogenesis in OPA1-deficient brown adipocytes, showing its role in glucose homeostasis and cold-induced thermogenesis.

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

The study examines how muscle resistance to stretch is affected by prior movement history, finding that small, slow pre-movements preserve resistance, while larger, faster movements reduce it.

The paper investigates how mitochondrial function changes with temperature in Drosophila species, finding that cold-sensitive species show greater reduction in complex I respiration and increased use of alternative substrates at low temperatures.

This study uses high-resolution ultrasound to assess arterial pathologies in atherosclerosis and aortic aneurysm mouse models, finding correlations between ultrasound metrics and histological changes.

This study compares metabolic responses to hypothyroidism in two mouse strains, finding that WSB/EiJ mice compensate for hepatic lipid metabolism disruption through white adipose tissue lipid mobilization, unlike C57BL/6J mice.

This study examines how transcutaneous electrical nerve stimulation affects motor unit firing during isometric contractions, finding increased electromyographic amplitude without altering discharge rates or correlation patterns.

This study identifies O-GlcNAc glycosylation as a regulator of bone marrow stromal progenitor fate and niche function, influencing osteogenic/adipogenic differentiation and hematopoiesis.

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

This study shows that C-low threshold mechanoreceptors (C-LTMRs) become pain-sensing neurons after spinal cord injury, leading to affective pain and increased respiratory rates in mice.

This study shows that loss of adipose mTORC2 leads to increased hepatic lipogenesis and hypertriglyceridemia, but simultaneous inhibition in both tissues causes severe insulin resistance.

This study investigates ergothioneine's protective effects against doxorubicin-induced cardiotoxicity in mice and finds it significantly reduces cardiac dysfunction without affecting tumor growth or chemotherapy efficacy.