Discover, rate, and discuss biology preprints.

This study examines how muscle mass and denervation affect maximal power and rapid force in adult females across their lifespan.

This study validates resazurin as a high-throughput proxy for metabolic rate in oysters, showing its correlation with oxygen consumption and its utility in assessing thermal stress and genetic variability.

This study shows that glucose and methylglyoxal affect plasma proteins, immune traits, and glucose homeostasis in zebra finches, with sex- and season-dependent variations.

This paper introduces Fetal Twin, a mechanistic computational model of fetal physiology to study heart-rate-variability biomarkers, revealing artifacts in beat detection and fidelity requirements for accurate biomarker interpretation.

This study shows autophagy prevents ER stress-induced tight junction barrier disruption by maintaining claudin-2 homeostasis and occludin localization.

This study shows that palmitoylation regulates mitochondrial transport of insulin across the endothelium, improving insulin sensitivity in insulin resistance.

This study shows that prenatal low-dose DBP exposure impairs placental vascular function and lipid metabolism differently in male and female fetuses.

This study uses molecular imaging to show that hypertension-induced inflammation and fibroblast activation in the heart and kidney are correlated and predict organ dysfunction.

This study shows that CBR4 is essential in mammals but not for skeletal muscle function, as muscle-specific Cbr4 knockout in mice did not cause measurable defects.

This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.

This study shows that removing GM3 gangliosides in cardiomyocytes slightly reduces heart size but does not protect against ischemia-reperfusion injury.

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

This study uses continuous glucose monitoring and indirect calorimetry in mice to assess metabolic responses to various physiological stressors, revealing dynamic changes in glycemia and energy expenditure.

This paper develops an algorithm called Algostim to synchronize neuromuscular electrical stimulation with breathing in mice with cervical spinal cord injury, showing improved chest movement with synchronized stimulation.

This study compares contractile properties of slow- and fast-contracting muscle fibers at 37°C and 25°C in older adults, finding greater similarity at body temperature.

This study shows that dynasore, a dynamin inhibitor, has hormetic effects on bone growth, stimulating elongation at low doses and inhibiting growth at high doses.

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

This study shows that GPR180 deficiency impairs mitochondrial function and first-phase insulin secretion in pancreatic β-cells without affecting insulin sensitivity.

This paper investigates the effects of chronic PTH excess in PHPT on adipose tissue in humans and finds no significant thermogenic or energy-dissipating changes, but identifies a selective secretory phenotype.