Discover, rate, and verify biology preprints.

RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans

Seasonal temperature extremes drive shifts in reproductive strategy in Cassiopea xamachana

This study shows that seasonal temperature extremes influence reproductive strategies in Cassiopea xamachana polyps, with warmer temperatures promoting strobilation but reducing ephyra fitness.

RhythmWriter: GPU-accelerated Contractility Quantification for Large Datasets

RhythmWriter quantifies contractile motion in hiPSC-CMs, enabling high-throughput drug screening and maturation assessment.

Cross-species multi-omics integration reveals lung alterations in acute kidney injury across mouse, pig, and human airway organoid models

This paper integrates multi-omics data across species to show AKI-induced lung alterations, identifying conserved pathways and human-validated targets for distant organ failure.

Agreement between Garmin and Ultrahuman wearables and their association with continuous glucose monitoring: an n-of-1 study

This study compares agreement between Garmin and Ultrahuman wearables and their association with continuous glucose monitoring in one adult, finding close agreement on sleep duration but variable heart rate and glucose correlations.

Matrix Metalloproteinase Response to Acute Resistance Exercise is Altered in Osteoarthritic Adults with Increased Muscle Collagen and PDGFRα+ Mesenchymal Cells

This study examines how MMPs respond to resistance exercise in knee OA patients, finding impaired ECM remodeling and altered PDGFR+ mesenchymal and satellite cell dynamics.

Food perception alone stimulates oviposition through serotonin signaling in Drosophila

This study shows that food perception alone, through olfactory signaling and serotonin receptors, stimulates oviposition in Drosophila without requiring nutrient intake.

Dietary nitrate does not alter the rate of torque development during maximal voluntary isometric or electrically evoked tetanic contractions in young men or women

Subtle Facial Skin Color Changes Enhance the Human Likeness of Artificial Agents: Insights from Pulse-Wave-Derived Modulation

This study shows that subtle facial skin color changes from pulse-wave signals enhance perceived human likeness of artificial agents, regardless of agent type or interoceptive sensibility.

Mitochondrial respiratory complexes, excitation-contraction coupling and mTOR signaling transcriptional programs are dysregulated in cardiometabolic HFpEF

This study identifies transcriptomic changes in HFpEF mouse hearts, showing mitochondrial respiratory complex downregulation, mTOR activation, and excitation-contraction coupling disruption.

Therapeutic acute intermittent hypoxia does not alter whole-brain cerebrovascular function in healthy individuals

This study examines the effects of therapeutic acute intermittent hypoxia on cerebrovascular function in healthy individuals and finds no significant changes in whole-brain blood flow or reactivity.

Subchondral bone remodeling in knee osteoarthritis is coupled to lipid mobilization from bone marrow adipocytes

This study investigates the link between lipid mobilization from bone marrow adipocytes and bone formation in knee osteoarthritis, finding that lipolysis is associated with osteogenic activity and can be pharmacologically modulated.

Pre-chlorotic Mg2+ deficiency impairs guard-cell PSII and leaf gas exchange in Vicia faba

This study shows that magnesium deficiency impairs guard-cell photosystem II and leaf gas exchange before visible chlorosis in Vicia faba.

Effective mean-field variables explain how biophysical parameters control firing rate and regularity in a spiking network

The paper shows that effective mean-field variables, not nominal parameters, best explain firing rate and regularity in a spiking network across various simulations.

MetAR: A semi-automated meta-analysis of skeletal muscle androgen receptors association with age

This study uses a novel R-based pipeline, MetAR, to analyze RNA-seq datasets and finds that androgen receptor expression declines with age in human skeletal muscle.

Does increasing the dose of relaxation strain augment the sarcomerogenic response to isometric resistance exercise?

This study tests if increasing relaxation strain during isometric exercise boosts sarcomerogenesis, finding greater SSN increases in burst contractions compared to sustained contractions.

Repeated Neuromuscular Electrical Stimulation Protocol Disrupts Muscle-to-Brain Signaling in Rats

This study shows that repeated neuromuscular electrical stimulation in rats leads to maladaptive muscle-to-brain signaling, including inflammation and reduced hippocampal markers, unlike acute stimulation benefits.

Proteomics of steady-state and culture-derived human erythropoiesis reveals the dynamics of erythroid stress

This study compares proteomic profiles of steady-state and cultured human erythroid progenitors, revealing how culture-induced stress alters protein expression and erythroid maturation dynamics.

FKBP12-BOUND CALCINEURIN CONTROL TMEM16A ACTIVITY

This study shows FKBP12 interacts with TMEM16A and CaN, modulating its activity through a heterotrimer complex, with FKBP12 acting as an auxiliary protein.

Excitation-contraction coupling plasticity is revealed upon RyR2 depletion in adult mouse ventricular myocytes

This study shows that adult mouse hearts maintain cardiac function despite significant RyR2 depletion through intrinsic ECC plasticity mechanisms.