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This paper evaluates genetically encoded voltage indicators using FLIM to measure absolute membrane potential, finding that rEstus-NI provides the highest sensitivity and accuracy.

This study profiles systemic immune changes in a murine OA model, finding reduced MHCII on macrophages and DCs, increased tolerogenic DCs, and shifts in T cell composition.

This study identifies NK2R as a key regulator of intestinal lipid metabolism and mucosal inflammation, showing bidirectional effects on lipid mobilization and immune responses.

This study shows that increased plasma viscosity affects endothelial and mural cell activity in capillaries, impairing flow dynamics and perfusion.

This study shows chronic kidney disease causes systemic metabolic failure across multiple organs, impairing cardiac function and stress resilience by depleting bioenergetic reserves.

This study investigates how walking speed affects the metabolic cost of balance control, finding that faster speeds reduce the energy needed to stabilize walking.

This study investigates how different photoperiods affect cotton growth and development by integrating physiological measurements and transcriptomics, revealing gene expression changes and regulatory pathways involved.

This paper shows that injecting a cobalt oxide time-release ion matrix (CoO-TRIM) accelerates skeletal muscle regeneration in injured mice without affecting healthy muscle.

This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.

This study quantifies seasonal plasticity in coral physiology and symbiont communities across three genera, revealing differences in stress resilience linked to environmental factors and genetic diversity.

SAAR improves exercise capacity in mice by enhancing fat oxidation and substrate availability through VEGF signaling and CD36-dependent fatty acid transport.

This study identifies a gut microbiota-muscle axis in C. elegans that protects against age-related motor decline by regulating mitochondrial fission through DRP-1.

This study shows that loss of SNX27 in intestinal epithelial cells disrupts barrier function and promotes inflammation in mice, with reduced SNX27 expression observed in human IBD.

This study investigates sex-specific effects of vitamin D supplementation on glucose homeostasis and gene regulation in aged mice, finding protective effects in males but not females.

This study shows that DENND5B is critical for dietary triglyceride absorption and that its deletion reduces body fat and increases intestinal fatty acid oxidation via autophagy in both sexes.

This paper describes an ultrasound-guided biopsy technique to collect supraclavicular brown fat and subcutaneous white fat from healthy individuals, and evaluates in vitro differentiation and gene expression of progenitor cells.

This study examines how umbilical cord structure affects heat transfer in mammals, finding that cord morphology influences fetal thermal resilience.

This study shows sustained visual signals in the primate cerebellar dentate nucleus are involved in visuomotor associative learning by enhancing discrimination of visual objects based on saccade direction.

The paper identifies a biphasic gene regulatory network in rat pituitary gonadotropes that controls the preovulatory hormone surge, showing FSH surge is driven by dynamic Fshb transcription rather than Lhb upregulation.