Discover, rate, and discuss biology preprints.

This study identifies a proteomic signature in humans following acute cold exposure that correlates with cardioprotective and anti-aging effects.

This paper shows that inhibiting SRPK1 in monocytes promotes angiogenesis by altering VEGF splicing from anti-angiogenic VEGF-A165b to pro-angiogenic VEGF-A165a in both human and mouse models of peripheral arterial disease.

This study develops an ex vivo multivisceral perfusion platform using Yorkshire pigs, showing improved organ preservation with iterative design improvements.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This study identifies early aging-related changes in muscle MERC ultrastructure and proteome, which are reversed by exercise, suggesting potential therapeutic targets for sarcopenia.

This study identifies CtBP as a redox state sensor that controls enteroendocrine cell fate in Drosophila by integrating metabolic signals with transcriptional regulation.

This study investigates how prolonged fasting and glucocorticoids affect DNA methylation in elephant seals, finding transient increases in blood methylation and decreased methylation in muscle cells with glucocorticoid exposure.

This study identifies a cytokine-mediated signaling pathway in Drosophila that coordinates systemic hypoxia tolerance, revealing sex-specific requirements and a regulatory role for HIF-1/sima.

This study shows that high-fat diet reduces Usp25m in mice, impairing TUG cleavage and glucose uptake during fasting, leading to insulin resistance in skeletal muscle.

The paper corrects a model error, reparameterizes it, and applies extreme value theory to derive a more accurate menopause age formula and distribution.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

This study investigates the biological mechanisms of orthorexia by examining gastric and facial responses to different types of foods in a non-clinical sample.

This paper measures free-swimming jellyfish metabolic rates using non-invasive volumetric laser scanning and finds they consume 2.5 times more energy than constrained animals.

This study identifies nuclear-encoded RNAs in mitochondria of rat skeletal muscle, with some miRNAs showing altered abundance after exercise training.

This paper uses UAV phenotyping and machine learning to predict barley root traits in the field, identifying genetic drivers of root gravitropism.

This study examines the effects of combined respiratory muscle training on sleep and cardiovascular metrics in a non-clinical population, finding improved heart rate variability but no changes in sleep quality.

This study shows that yo-yo dieting in mice causes lasting gut microbiota changes and alters brain function, leading to increased hedonic eating behavior.

This study shows that older mice experience more severe sepsis with higher inflammation, vascular permeability, and organ damage compared to younger mice.

This study shows that dopamine regulates photoreceptor photoresponse properties in lamprey differently than in jawed vertebrates.

This study shows that remote ischaemic preconditioning protects the heart by releasing GLP-1, which relaxes cardiac pericytes and reduces no-reflow.