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The paper develops a closed-loop framework for designing receptor-selective cell-penetrating peptides using multi-objective optimization and evaluates its effectiveness through experimental validation.

This study investigates how task and aging affect semantic processing in the brain, finding that both TPC and ATL respond preferentially to thematic relationships and that aging leads to shifts in semantic control and processing.

This study establishes a rodent model of supraspan memory and shows that dorsal hippocampus supports high-load memory while ventral hippocampus supports egocentric strategies.

This study shows that phosphate availability influences cell wall remodeling in C. albicans under oxidative stress, linking nutrient sensing to fungal mechanical resilience.

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

This paper identifies an intracellular mechanosensory complex in intestinal smooth muscle that amplifies signaling from the sarcoplasmic reticulum, independent of extracellular calcium, to regulate contractility.

This study shows that bacterial inoculation induces DNA methylation changes in corals, which correlate with gene expression and affect stress resilience.

This paper introduces a real-time forecasting framework for livestock disease outbreaks, showing improved accuracy after the outbreak peak and consistent spatial forecast skill.

This study uses cell-cell fusion to investigate how mitotic and interphase nuclei interact in shared cytoplasm, revealing checkpoint override events and plasticity in cell cycle control.

This study shows BRWD1 is essential for maintaining epigenetic states in germinal center B cells, affecting their function and subset identity.

The paper examines frontolimbic functional connectivity development from birth to emerging adulthood, finding that fronto-hippocampus and fronto-amygdala connectivity differentiate with distinct developmental timing and sensitivity to adversity and cognitive ability.

This paper develops a bireporter recombinant SARS-CoV-2 Omicron BA.5 strain for tracking viral infections and testing antivirals and neutralizing antibodies in vitro and in vivo.

This study uses cryogenic electron tomography to visualize the mechanism of membrane perforation during rhesus rotavirus entry, linking structural data with live-cell imaging.

This paper introduces Bayesian pulse deconvolution to improve vascular waveform analysis by jointly solving signal filtering, pulse timing detection, and pulse shape extraction, achieving significant error reductions in simulations and real-world data.

This study establishes and characterizes immortalized human choroidal melanocytes that retain melanocytic function and are suitable for gene editing.

PePApipe is a bioinformatics pipeline for ASFV genome analysis that integrates multiple tools into an automated workflow, enabling rapid and reproducible genomic analysis with minimal bioinformatics expertise.

This study shows paclitaxel induces cancer cell contraction via GEF-H1 dissociation from microtubules and RhoA/ROCK activation, with tubulin acetylation regulating this process.

NDC-1171, a SERCA pump modulator, preserves cardiac function in DMD mice but does not improve skeletal muscle function.

This study shows that Coxiella burnetii forms a SCV-like persistent form under hypoxia, enhancing its survival and infectivity.

This study identifies pericyte-derived cancer-associated fibroblasts (CAFs) in glioblastoma, showing their association with poor survival and increased abundance after chemoradiotherapy.