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This study characterizes PHOSPHO2 as a novel Mg2+-dependent, NEM-sensitive phosphatase with PAP activity toward multiple lipid substrates.

This paper introduces PEP-seq, a method linking genetic variants to transcriptomic states, and shows it can detect functional effects of eQTLs and nonsense-mediated decay.

The paper describes the development of En-ISPmu1, a modified TnpB nuclease, and demonstrates its ability to achieve targeted genome integration in mouse liver with a single AAV vector.

This study identifies the binding site of CVN293 on THIK-1 K2P channel and reveals its allosteric inhibition mechanism through cryoEM structures and functional validation.

This study shows that Parkin deficiency alters genetic dependencies for neuronal survival, identifying key pathways and genes involved in this rewiring.

This study uses a 3D fluid-structure interaction model to show that pediatric roller-pump settings with similar oxygen delivery can result in different shear and washout environments, suggesting the need for joint evaluation of these metrics.

The paper introduces the ZenoTOF 8600 system, which enhances proteomics by increasing ion flux and improving precursor identification and quantification in DIA mode.

This paper introduces a method to quantify tissue composition using Raman spectroscopy, validated on cartilage with high accuracy compared to biochemical assays.

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

This study improves ethylene glycol production from xylose in E. coli using two-stage dynamic control, achieving 140 g/L in 70 hours with 92% theoretical yield.

This paper develops a CRISPR-Cas9 system for Anaerocellum bescii, enabling gene deletions and vector maintenance through thermostable Cas9.

This study shows RGS9 supports glucose-stimulated insulin secretion in male mouse islets by dampening inhibitory signaling through Gi/o.

VIPER-seq improves virus detection in plants by enriching viral small RNAs using protein-mediated methods, showing better sensitivity in low-titre infections.

The paper introduces normalized versions of Effort-To-Compress (ETC) to enable fair comparisons of symbolic complexity across different sequence lengths, alphabet sizes, and compositions.

This paper introduces SPOT-Mut, a graph convolutional neural network that predicts clonal mutations from spatial transcriptomics data, achieving high precision and recall for key driver genes.

This study examines cave-dwelling planariids in Croatia, revealing multiple genera, increased diversity, and independent cave colonization events, highlighting convergent evolution of cave traits.

This study quantifies how dose-response relationships in signaling systems affect information transmission under various noise distributions and identifies design principles for improved signaling fidelity.

The paper measures folding thermodynamics of SpA domains and identifies a stability gradient that facilitates efficient secretion.

The paper develops a kinetic model to distinguish between matrix-associated and solution-driven calcium phosphate mineralization in osteogenic cultures and shows that total mineral amount does not indicate matrix contribution.