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This study shows that supplementing alpha-ketoglutarate (aKG) improves T cell function and immunotherapy effectiveness in NSCLC by reversing epigenetic changes associated with T cell exhaustion.

CATFISHR integrates transcriptomic and copy-number data to improve malignant cell identification in scRNA-seq, achieving high accuracy across multiple datasets and identifying previously missed malignant populations.

This study identifies a lung-to-aorta inflammatory program driven by influenza that exacerbates atherosclerosis through shared circadian and Hippo/YAP pathway suppression.

VenusGenome improves microbial genome representation learning by using a genome-aware masked autoencoder, achieving high performance in phenotype prediction and gene-level tasks.

This study examines how visitor density and human interactions affect the behavior of teleost fish in public aquaria, finding species-specific responses and distinct noise impacts.

This study characterizes the pharmacokinetic properties of ent-verticilide, identifying limited intestinal availability and CYP-mediated metabolism as key factors affecting its oral exposure.

This study shows that high SETDB1 protein expression in bladder cancer is linked to shorter overall survival and specific tumor features.

CRISPR-dPCR quantifies CRISPR knock-in by distinguishing integration from donor abundance and background, using multiplex digital PCR with orthogonal strategies.

The paper investigates how spatial and transcriptional dynamics at Cd4 and Cd8 loci influence T cell lineage choice in the thymus, revealing locus-specific chromatin environments that drive differentiation.

The paper uses network analysis, MD simulations, and experiments to identify critical residues in human PrP that affect structural stability and misfolding.

This study reveals the unliganded active state of the β2-adrenergic receptor using pressure-resolved DEER and ProGuide modeling, showing pressure-dependent conformational changes and allosteric coupling.

This study evaluates the effectiveness of combining Azospirillum brasilense with cytidine or seedling exudate to improve pea drought resilience, finding that cytidine enhances drought tolerance and rhizosphere diversity.

The paper investigates how input encoding and spike detection methods affect neural representations and reservoir computing performance in biological neural networks for multiclass time-series classification.

The paper uses CRISPR-LICHT to screen SOX2 targets in human brain organoids, identifying 28 new genes involved in neural progenitor lineage expansion and survival.

The paper identifies brain-specific functions of NDD-associated genes by analyzing gene expression and regulatory mechanisms across tissues.

The paper reports the genome sequences of three marine Saccharomyces cerevisiae strains and assesses their salt and inhibitor tolerance compared to terrestrial strains.

This study links hemodynamic responses and neuronal activity in prefrontal cortex across humans and macaques during abstract sequence viewing, showing functional homology and distinct spiking dynamics.

This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.

This study identifies Neuromedin-U (NMU) and Endothelin-1 (ET-1) as key signaling factors influencing cardiomyocyte differentiation and electrophysiology in human cardiac organoids.