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Perinatal exposure of mice to a Pb, As, Cd and Cr(VI) mixture at EPA levels impaired recognition memory, raised anxiety-like behavior, and altered mPFC neuron function.

Multi-omic profiling of unicellular Mesotaenium and filamentous Zygnema under osmotic and salt stress reveals a conserved protein and cell-wall remodeling chassis driving acclimation in land plants' closest algal relatives.

Comparative mushroom genomics and fly-rearing experiments reveal an alternative psilocybin biosynthetic gene cluster in Inocybe corydalina, horizontal transfer of the canonical cluster, and incomplete defense against dipteran larvae.

Across 109,626 wood density records from 16,829 plant species (GWDD v.2), intraspecific variation explains 15% of global variance, tracks interspecific environmental gradients at 20-30% magnitude, and limits single-plant predictability.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

Thermostable RNaseH release of barcoded cDNA keeps sections intact for CODEX imaging, yielding same-section whole-transcriptome and protein maps plus CODEX-guided spot deconvolution in FFPE tissues.

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Adipocyte-specific deletion of Prdm16 ablates beige fat identity, derepresses the secreted enzyme Qsox1, and induces vascular fibrosis, angiotensin II hyperreactivity, and elevated blood pressure in mice.

MaAsLin 3 fits hurdle models separating microbial prevalence (augmented logistic) and abundance (median-adjusted log-linear) associations, improving precision over existing differential abundance tools and showing 77% of IBD associations are prevalence-driven.

Constrained-tree hypothesis testing on 4,290 core eukaryotic protein clusters attributes 50% of likelihood weight to Asgard archaea; Alphaproteobacterial ancestry is largely confined to oxidative phosphorylation and iron-sulfur cluster biogenesis.

Boosted regression trees predict, one year ahead, where human tick-borne encephalitis (TBE) cases are likely in Europe (AUC 0.85 regional, 0.82 municipal), with probability rising in central-western Europe.

Low femoral trabecular anisotropy and bone volume fraction mark suspensory/bridging mammals, and a phylogenetic discriminant model classifies extinct Palaeopropithecus ingens and Megaladapis edwarsi as suspensory.

A Shiny web platform pulls together gnomAD frequencies, UK Biobank LDL-C associations, AlphaMissense, LDLR deep mutational scanning and ClinVar/HGMD to draft ACMG/AMP evidence for familial hypercholesterolemia variants.

In hip osteoarthritis (OA) versus femoroacetabular impingement (FAI) synovium, inflammatory EREG+ lining fibroblasts expand and co-localize more with COL1A1+ fibrotic macrophages; FGF2-SDC4 is their top predicted interaction.

Orbitrap Astral Zoom upgrades enable 270 Hz DIA scanning, identifying 7184 protein groups at 500 samples/day and >12,000 proteins from fractionated HEK293 in 2.7 h.

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.

Contrastive scoring of protein variants across alternative backbone structures with inverse folding models (Conformational Biasing) predicts mutations that shift conformational equilibria and tune effector binding, catalysis, and labeling specificity.

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.