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Calcium and actomyosin pulses drive tricellular zipping to remodel epithelial cell-cell junctions and facilitate cell packing

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

TRPV4 antagonist efficacy in a post-hemorrhagic hydrocephalus pig model

This study tests TRPV4 antagonism in a pig model of post-hemorrhagic hydrocephalus, showing it prevents ventriculomegaly and reduces intracranial pressure.

Development of appropriate sensorimotor recalibration for a de novo skill

This study shows that implicit recalibration becomes flexible after prolonged training on novel sensorimotor mappings, allowing context-specific adaptation.

CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models

This study shows CD40L and IFN-γ induce inflammation and neurodegeneration in human stem cell-derived microglia, suggesting CD40L blockade as a potential MS therapy.

Synthetic reaction-diffusion patterning in mammalian cells

This study designs synthetic reaction-diffusion circuits in mammalian cells to generate spatial patterns with controllable spatial scales.

NPlasmid-seq: Cas9-encoded terminal signatures enable molecule-level nanopore quality control of vector and IVT-template plasmids

NPlasmid-seq detects sub-percent contamination and sequence heterogeneity in plasmid preparations using Cas9-encoded terminal signatures, revealing structural variants missed by consensus-based methods.

Serum Calprotectin as predictor of Rheumatoid Arthritis disease severity and Mortality

This study evaluates serum calprotectin as a biomarker for disease activity, severity, cardiovascular risk, and mortality in inflammatory rheumatic diseases, finding it to be a better predictor than CRP in certain contexts.

Predicting seabird-vessel interactions from bird-borne data alone

This paper develops a method to predict seabird-vessel interactions using only seabird telemetry data, showing high accuracy but limitations in distinguishing fishing from nonfishing vessels.

Mapping and Probing the Substrate Scope of a Ketoamide-Forming Splicease by Computational Design

The paper uses computational methods to design and evaluate splicease variants for generating diverse ketoamide substrates, finding that top-scoring peptides are spliced more efficiently than single-point mutants.

NTAD: A longitudinal neuroimaging dataset of Alzheimer's disease pathology

The paper introduces a longitudinal neuroimaging dataset of Alzheimer's disease pathology, including multimodal data from patients and controls, to identify and validate novel biomarkers.

Targeted cancer ablation via programmable sensing of amplified oncogenic RNA

This paper introduces ORCA, a platform that uses oncogenic RNA sensing to target and ablate cancer cells, demonstrating efficacy in colorectal cancer models.

GMP-Cor: Quantifying Transcriptional Dysregulation in Antibiotic Tolerance and Persistence

This study quantifies transcriptional dysregulation in antibiotic tolerance using single-cell RNA-seq and introduces GMP-Cor to analyze gene-gene correlations in disrupted growth-arrest states.

Extracellular DDR1 targeting remodels collagen-rich tumor stroma and local immunity

This study develops DDR1-targeting nanobodies that remodel collagen-rich tumor stroma and immune compartments, enhancing tumor control without direct tumor-cell inhibition.

Resonant Recognition Model analysis of cGAS: conserved spectral frequencies and a divergent naked mole-rat phase signature

This paper uses the Resonant Recognition Model to analyze cGAS and FANCI sequences across species, identifying conserved spectral features and divergent phase signatures in naked mole-rats.

A validation approach for RNA structures based on deep-learning 3D-structure predictions

This paper extends a protein structure validation method to RNA, showing it can detect errors in low-resolution structures where map-based methods fail.

Metabolic complexity in the human brain supports metastable network dynamics and declines in normative ageing

This study investigates metabolic complexity in the human brain using PET and fMRI, finding that metabolic entropy correlates with network metastability and declines with age.

Serotype specific anti-capsular polysaccharide IgG associated with colonizing and invasive group B streptococcus in pregnant woman-newborn dyads

The paper quantifies serotype-specific anti-capsular polysaccharide IgG in pregnant women and newborns to assess protection against invasive group B streptococcus (GBS) disease.

Optimizing non-invasive assessment of gastric activity: a fully automated channel-wise pipeline for multi-electrode electrogastrography

This paper develops a fully automated pipeline for EGG signal processing to improve artifact rejection and signal quality, showing improved performance over existing methods.

Stable large-scale network architecture and structured individual variability in the awake mouse brain

The paper introduces the Awake Mouse Connectome Project (AMCP), a dataset of 212 awake mice, and presents functional network atlases and analysis tools for studying brain connectivity and variability.

Prokaryotic Community Structures in the Bering and Chukchi Seas

The paper characterizes bacterial communities in the Bering and Chukchi Seas using 16S rRNA gene sequencing, finding that water mass, salinity, and bloom stage shape community structure.