Discover, rate, and verify biology preprints.

Detecting deception in event narratives: the analysis of response latencies and error rates to unexpected questions.

This study uses response latencies and error rates to unexpected questions to detect deception in narratives, finding higher values in deceptive participants and demonstrating diagnostic potential with machine learning.

KobA mediates kinesin-1-dependent transport of dynein-dynactin to microtubule plus ends

This study identifies KobA as a kinesin-1-binding protein that facilitates dynein-dynactin transport to microtubule plus ends in Aspergillus nidulans.

Loss of cell-identity DNA methylation tracks division history, not DNA damage

The paper tests whether DNA damage drives aging by analyzing cell-identity DNA methylation changes in human fibroblasts and finds that division history, not DNA damage, correlates with loss of identity information.

Mapping AMPA and NMDA receptors at mouse brain hippocampal synapses by cryo-ET

The paper maps AMPA and NMDA receptors at mouse hippocampal synapses using cryo-ET, revealing their distribution and relationship to glutamate release sites.

Fibronectin-Assisted Coating of Low-Molecular-Weight Fucoidan Creates a Biomimetic Interface for Endothelialization of Cobalt-Chromium Stents

This paper develops a fibronectin-LMWF coating for Co-Cr stents that enhances endothelialization by improving cell adhesion, proliferation, and cytoskeletal organization without cytotoxicity.

Hmox1/CO regulates retina regeneration via modulation of Wnt/β-catenin signalling and induction of vaspb in zebrafish

This study identifies Hmox1/CO as a regulator of zebrafish retina regeneration through Wnt/β-catenin signaling and vaspb induction, with implications for mammalian regeneration.

VIGAT: VLM-guided gene activity quantification from single-cell ATAC-seq

VIGAT uses a vision-language model to quantify gene activity from single-cell ATAC-seq by analyzing accessibility patterns and genomic annotations across marker genes.

Circuit regulation along an activity continuum shapes flexible and stable representations during learning

The paper identifies mechanisms in the medial entorhinal cortex that balance representational flexibility and stability during learning through excitatory and inhibitory neuronal activity dynamics.

Transplantation of human iPSC-derived retinal cells in the cone-dominant Northern tree shrew

This study transplants human iPSC-derived retinal cells into Northern tree shrews and shows improved survival with a complex immunosuppression treatment.

Differential effects of chronic hypertension and sex on vascular density along the septotemporal axis of the hippocampus in a rat model of VCID

This study examines how chronic hypertension and sex affect vascular density in different regions of the hippocampus in rats, finding sex-specific changes in vascular structure.

PHASOR: An Open-Source Pipeline for Hidden Markov Model Analysis of Stimulus-Locked Retinal Multielectrode-Array Population Activity

PHASOR is a pipeline that analyzes retinal multielectrode-array data using hidden Markov models to link stimulus timing with population activity states.

IDENTIFICATION OF CANDIDATE GENES UNDERLYING A NOVEL QTL FOR ROOT LENGTH AND DIAMETER IN BARLEY IN RESPONSE TO SALINITY

This study identifies a QTL on chromosome 2H in barley affecting root length and diameter under salinity, and finds differentially expressed candidate genes in that region.

Self-Other Neural Representational Distinction is Associated with Distorted Social Predictions in Social Anxiety

This study investigates how social anxiety affects self-other neural distinctions and social predictions, finding that higher SA correlates with greater self-other representational separation in the pgACC and altered prediction tracking in the precuneus.

Multimodal characterization of putative pan-inhibitory viral constructs in macaque monkeys

This study evaluates three pan-inhibitory viral constructs in macaques to assess their efficacy in targeting inhibitory neurons and modulating neural activity.

Effects Of Lymphocyte Trafficking on Antiretroviral Drug Distribution within the Lymph Node

This study shows that blocking lymphocyte entry into lymph nodes increases intracellular drug concentration for some antiretroviral drugs, but not others, due to changes in extracellular fluid volume.

Influence of antibody-antigen interaction on fluorescence of Rhodamine 6G conjugated to the antibodies measured in human serum

This study measures how antibody-antigen interactions affect the fluorescence of Rhodamine 6G-conjugated antibodies in human serum, showing non-linear spectral changes.

Reducing the Risk of Gradient Induced EEG Hardware Heating During Simultaneous EEG-fMRI

This study shows that placing EEG amplifiers inside the MRI bore increases heating risk from gradient switching, and suggests solutions to mitigate this risk.

Extensive membrane lipid remodeling at the host-parasite interface of Toxoplasma gondii

This study identifies the transbilayer distribution of phosphoinositides in Toxoplasma gondii, revealing symmetric localization in the parasitophorous vacuole membrane, contrasting with asymmetric distribution in the parasite plasma membrane.

A medial entorhinal connectome reveals compartmentalized microcircuit architecture

This paper maps the synaptic architecture of the medial entorhinal cortex at synapse resolution, revealing compartmentalized microcircuit organization and potential mechanisms for spatial navigation.

Long term survival of chronically demyelinated axons in the taiep rat

The paper examines axon survival in chronically demyelinated taiep rats and finds that small diameter axons can survive for months with increased glial support.