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Unpredictable chronic stress redistributes novelty-evoked exploratory space use and yields method-dependent identification of resilient-like archetypes in zebrafish

This study shows UCS in zebrafish alters exploratory behavior patterns, with method-dependent identification of resilient-like archetypes.

Deep-intronic variants in USH2A: the importance of model selection in variant interpretation and pathogenicity assessment

The paper evaluates two USH2A variants using minigene assays and zebrafish models, finding that one variant may be benign and the other not pathogenic.

Lac1-dependent ceramide synthesis couples septum assembly to cell separation in Schizosaccharomyces pombe

This study shows that Lac1-dependent ceramide synthesis is essential for proper septum assembly and cell separation in fission yeast.

The Reasoning Paradox in Scientific Sandboxes: Why Extended Reasoning Fails in Autonomous Bioinformatics and How to Fix It.

This paper identifies two failure modes in extended reasoning models within bioinformatics tasks and introduces DTDR to improve accuracy and reduce errors.

A Physics-Constrained Marcus-Theory Optimization Framework Restores Parameter Identifiability in Deep-Pocket Oncogenic Drug Kinetics: A KRAS G12C and STAT3 Case Study

The paper develops a physics-constrained framework to improve parameter identifiability in drug kinetics by incorporating dielectric permittivity changes, validated with synthetic and real data.

Understanding range-wide immune gene variation in an endangered big cat (Panthera tigris)

This study assesses non-MHC immune gene diversity in tigers using whole-genome data, finding higher variation at immune receptor genes and signs of balancing selection on Toll-like receptors.

PHATE-Derived Ancestry Coordinates Capture Continuous Population Structure in Human Genomic Data

This paper shows PHATE can better capture continuous population structure in genomic data than PCA or UMAP by tuning scale and balancing populations.

Protection against disseminated disease following reinfection with Mycobacterium tuberculosis requires CD8+ lymphocytes

This study shows that CD8+ lymphocytes are essential for preventing Mtb dissemination during reinfection, highlighting their non-redundant role in concomitant immunity.

A noncanonical function of Dicer fuels self-dsRNA-driven inflammation

This study identifies a noncanonical role for Dicer in regulating self-dsRNA sensing and innate immune responses to self-derived double-stranded RNA.

Yap is a key regulator of tracheoesophageal separation during foregut development

This study identifies Yap as a critical regulator of tracheoesophageal separation during foregut development, showing that its loss causes a distinct Type A EA/TEF phenotype.

Oligodendrocytes may provide the extra density of α-synuclein filaments from multiple system atrophy

The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.

WhaleSonic: Recordings of cetacean vocal behaviour with hydrophone arrays in Northern Norway

WhaleSonic provides a raw acoustic dataset of cetacean vocalizations in Northern Norway, supporting multichannel algorithms for source separation and communication analysis.

Accumulation of two distinct alleles causes astringency loss in cultivated polyploid persimmon

This study identifies the TAN gene as the causal factor for astringency loss in PCNA persimmon cultivars through haplotype-resolved forward genetics and long-read sequencing.

TileScope quantifies spatial gene expression relationships beyond colocalization

TileScope quantifies spatial gene expression relationships beyond simple colocalization, distinguishing regional enrichment from internal covariation in glioblastoma and other tissues.

Res ipSAE adhuc loquuntur: What the directionality of predicted aligned error in cofolding models can tell us about scoring diverse molecular complexes

This paper introduces ipSAE, a directional scoring framework for assessing confidence in predicted biomolecular complexes, showing improved performance over existing methods in protein-ligand and protein-DNA interactions.

Monounsaturated fat prevent, whereas saturated fat promote, cholesterol crystals in cytoplasmic lipid droplets

This study shows monounsaturated fats reduce cholesterol crystals in lipid droplets, while saturated fats promote their formation in mice with MASH.

BundleMorphometry: Spatially Resolved White Matter Bundle Shape Analysis Using Nonlinear Streamline-based Registration

BundleMorphometry quantifies local white matter bundle shape using nonlinear registration, revealing deformation patterns in glioma and Parkinson's disease datasets.

Evolution Shapes Cortical Interneuron Migration

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

Parameter-Efficient Adaptation of Protein Language Models for Dual-Target Antimicrobial Peptide Discovery Under Strict Homology Constraints

This paper develops a parameter-efficient transfer learning framework to discover antimicrobial peptides with high potency and low cytotoxicity using protein language models.

scSTEC: Annotating Chromatin Subcompartments from Individual Single-Cell Hi-C Data via Direct Two-Dimensional Embedding and Chromosome-wise Consensus

scSTEC directly annotates chromatin subcompartments from individual single-cell Hi-C matrices without imputation or cross-cell sharing, achieving results comparable to scGHOST with greater interpretability.